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Value of an Additional Review for Eosinophil Quantification in Esophageal Biopsies
- Source :
- Journal of Pediatric Gastroenterology & Nutrition. 61:65-68
- Publication Year :
- 2015
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2015.
-
Abstract
- Eosinophilic esophagitis (EoE) requires a peak count of 15 eosinophils per high-power field (hpf). Herein, the peak eosinophil count specified by a pathologist was compared with the second review of a research assistant. Of 477 biopsies, 106 had a peak count between 1 and 14 eosinophils/hpf cited in the pathology report, and 23/106 (22%) had ≥15 eosinophils/hpf on second review. The pathology report detected potential EoE with 99% specificity, but 80% sensitivity. As such, an additional review of esophageal biopsies yields higher eosinophil counts in ∼5% of cases. We propose that biopsies with a count between 1 and 14 eosinophils/hpf require further investigation because ∼22% may yield a potential EoE diagnosis.
- Subjects :
- medicine.medical_specialty
Pathology
animal structures
Biopsy
Gastroenterology
Article
Leukocyte Count
Esophagus
Reference Values
Internal medicine
medicine
Humans
Eosinophilic esophagitis
Observer Variation
medicine.diagnostic_test
business.industry
Extramural
Eosinophilic Esophagitis
respiratory system
Eosinophil
medicine.disease
Eosinophils
medicine.anatomical_structure
Reference values
Pediatrics, Perinatology and Child Health
Observer variation
business
Subjects
Details
- ISSN :
- 02772116
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Journal of Pediatric Gastroenterology & Nutrition
- Accession number :
- edsair.doi.dedup.....e6f59397ced2131897095f51f9aa5b9d