Back to Search
Start Over
Characterization of the Human CD8(+) T Cell Response following Infection with 2009 Pandemic Influenza H1N1 Virus
- Source :
- Journal of Virology, 85(22), 12057-12061. American Society for Microbiology
- Publication Year :
- 2011
- Publisher :
- American Society for Microbiology, 2011.
-
Abstract
- The 2009 H1N1 influenza pandemic provided an opportunity to study human virus-specific T cell responses after infection with a novel influenza virus against which limited humoral immunity existed in the population. Here we describe the magnitude, kinetics, and nature of the virus-specific T cell response using intracellular gamma interferon (IFN-γ) staining and fluorochrome-labeled major histocompatibility complex (MHC) class I-peptide complexes. We demonstrate that influenza virus-infected patients develop recall T cell responses that peak within 1 week postinfection and that contract rapidly. In particular, effector cell frequencies declined rapidly postinfection in favor of relatively larger proportions of central memory cells.
- Subjects :
- Adult
Male
Time Factors
Adolescent
T cell
Immunology
Population
CD8-Positive T-Lymphocytes
medicine.disease_cause
Major histocompatibility complex
Microbiology
Virus
Interferon-gamma
Young Adult
Influenza A Virus, H1N1 Subtype
Virology
Influenza, Human
medicine
Influenza A virus
Cytotoxic T cell
Humans
Interferon gamma
education
education.field_of_study
biology
Staining and Labeling
Histocompatibility Antigens Class I
Middle Aged
medicine.anatomical_structure
Insect Science
Humoral immunity
biology.protein
Pathogenesis and Immunity
Female
medicine.drug
Subjects
Details
- ISSN :
- 10985514 and 0022538X
- Volume :
- 85
- Issue :
- 22
- Database :
- OpenAIRE
- Journal :
- Journal of Virology
- Accession number :
- edsair.doi.dedup.....e6f078b76926225028ec9f5351b66c13