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Impairment of Digoxin Clearance by Coadministration of Quinidine
- Source :
- The Journal of Clinical Pharmacology. 21:396-400
- Publication Year :
- 1981
- Publisher :
- Wiley, 1981.
-
Abstract
- Seven healthy volunteers received a single 1.0-mg dose of intravenous digoxin in a drug-free control trial and again during concurrent therapy with therapeutic doses of quinidine. Digoxin kinetics were determined from multiple serum digoxin concentrations measured during 72 hours after dosage. Compared to the control state, quinidine coadministration reduced mean digoxin volume of distribution (15.1 vs. 12.4 l./kg), prolonged its elimination half-life (47.7 vs. 75.7 hours), and significantly reduced total clearance (6.06 vs. 2.18 ml/min.kg). Both renal and extrarenal digoxin clearances were impaired by quinidine. In nine cardiac patients receiving long-term digoxin therapy (0.25 mg twice daily), quinidine coadministration elevated mean morning digoxin levels from 1.37 to 2.0 ng/ml (P less than 0.001) and evening levels from 1.44 to 1.97 ng/ml (N.S.). If digoxin concentrations at the site of action are increased by quinidine, the interaction is likely to be of clinical importance in many patients.
- Subjects :
- Adult
Male
Quinidine
Digoxin
Evening
Heart Diseases
Pharmacology
Random Allocation
Healthy volunteers
polycyclic compounds
medicine
Humans
Drug Interactions
Infusions, Parenteral
Pharmacology (medical)
cardiovascular diseases
Biotransformation
Morning
Volume of distribution
Serum digoxin
business.industry
Middle Aged
carbohydrates (lipids)
Kinetics
Anesthesia
Drug Therapy, Combination
Female
business
Site of action
Half-Life
medicine.drug
Subjects
Details
- ISSN :
- 00912700
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- The Journal of Clinical Pharmacology
- Accession number :
- edsair.doi.dedup.....e6efa43c02c4d3bbe42a07e8893055b0