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Medulloepithelioma with heterologous osteoid component: a case report and review of literature
- Source :
- Child's Nervous System. 35:1035-1039
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Medulloepithelioma is a rare brain tumor that has been classified as embryonal tumor with multilayered rosettes (ETMR) if it harbors C19MC amplification. In rare instances, it shows evidence of heterologous differentiation. We report a case of a 10-year-old female who presented with headache, squint, and minimal left sided weakness of 1 week duration. Microscopy revealed a small round blue cell tumor with focal glandular and tubular differentiation. In one focus, well-developed osteoid was identified. The tumor labeled with LIN28A immunostain. Unusual features can be encountered in medulloepithelioma which should be in the differential diagnosis of CNS embryonal tumors. Full description of the case with review of the literature and comparison between cases with and without heterologous elements is presented.
- Subjects :
- medicine.medical_specialty
Pathology
Brain tumor
Heterologous
03 medical and health sciences
0302 clinical medicine
Humans
Neuroectodermal Tumors, Primitive
Medicine
Child
Brain Neoplasms
business.industry
Osteoid
Ossification, Heterotopic
Cytogenetics
General Medicine
medicine.disease
Embryonal tumors
030220 oncology & carcinogenesis
Pediatrics, Perinatology and Child Health
Female
Neurology (clinical)
Medulloepithelioma
Differential diagnosis
business
030217 neurology & neurosurgery
Immunostaining
Subjects
Details
- ISSN :
- 14330350 and 02567040
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Child's Nervous System
- Accession number :
- edsair.doi.dedup.....e6eaf46dd21faa6d4ce52d7ccdb622ba