Back to Search
Start Over
rpoB gene mutations in clinical isolates of multidrug-resistant Mycobacterium tuberculosis in northern Lima, Peru
- Source :
- Microbial drug resistance (Larchmont, N.Y.). 11(1)
- Publication Year :
- 2005
-
Abstract
- In many developing countries and outside hospital settings, the characteristics of endemic Mycobacterium tuberculosis strains resistant to multiple drugs remain unknown. In a community-based referral and therapy program in northern Lima, Peru, beginning in 1996, patients found to be failures on standard regimens were referred for drug-susceptibility testing of their isolates, and those found to be infected with M. tuberculosis isolates resistant to at least rifampin were treated with individualized regimens based on their infecting strains. Isolates from 42 of these patients were subjected to DNA sequencing of the rpoB gene region responsible for rifampin resistance. We determined the frequency of types of mutations in the rpoB gene among these Peruvian isolates.
- Subjects :
- Microbiology (medical)
Tuberculosis
Immunology
Biology
Gene mutation
Microbiology
DNA sequencing
Mycobacterium tuberculosis
Peru
medicine
Humans
Multidrug-Resistant Mycobacterium tuberculosis
Gene
Antibiotics, Antitubercular
Tuberculosis, Pulmonary
Pharmacology
Drug Resistance, Microbial
DNA-Directed RNA Polymerases
Sequence Analysis, DNA
biology.organism_classification
rpoB
medicine.disease
Virology
Rifampin resistance
Mutation
Rifampin
Subjects
Details
- ISSN :
- 10766294
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Microbial drug resistance (Larchmont, N.Y.)
- Accession number :
- edsair.doi.dedup.....e6e4f26c7f4ea21bf4b5dffb41df9bc6