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rpoB gene mutations in clinical isolates of multidrug-resistant Mycobacterium tuberculosis in northern Lima, Peru

Authors :
R. Timperi
Mercedes C. Becerra
Sonya Shin
Alexander Sloutsky
Barbara G. Werner
Jaime Bayona
V. Naroditskaya
Paul Farmer
Source :
Microbial drug resistance (Larchmont, N.Y.). 11(1)
Publication Year :
2005

Abstract

In many developing countries and outside hospital settings, the characteristics of endemic Mycobacterium tuberculosis strains resistant to multiple drugs remain unknown. In a community-based referral and therapy program in northern Lima, Peru, beginning in 1996, patients found to be failures on standard regimens were referred for drug-susceptibility testing of their isolates, and those found to be infected with M. tuberculosis isolates resistant to at least rifampin were treated with individualized regimens based on their infecting strains. Isolates from 42 of these patients were subjected to DNA sequencing of the rpoB gene region responsible for rifampin resistance. We determined the frequency of types of mutations in the rpoB gene among these Peruvian isolates.

Details

ISSN :
10766294
Volume :
11
Issue :
1
Database :
OpenAIRE
Journal :
Microbial drug resistance (Larchmont, N.Y.)
Accession number :
edsair.doi.dedup.....e6e4f26c7f4ea21bf4b5dffb41df9bc6