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Metabolic alterations in focally activated primary somatosensory cortex of α-chloralose-anesthetized rats measured by 1H MRS at 11.7 T
- Source :
- NeuroImage. 28:401-409
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- Previously, magnetic resonance spectroscopy studies of alterations in cerebral metabolite concentration during functional activation have been focused on phosphocreatine using 31P MRS and lactate using 1H MRS with controversial results. Recently, significant improvements on the spectral resolution and sensitivity of in vivo spectroscopy have been made at ultrahigh magnetic field strength. Using highly resolved localized short-TE 1H MRS at 11.7 T, we report metabolic responses of rat somatosensory cortex to forepaw stimulation in alpha-chloralose-anesthetized rats. The phosphocreatine/creatine ratio was found to be significantly decreased by 15.1 +/- 4.6% (mean +/- SEM, P < 0.01). Lactate remained very low (approximately
- Subjects :
- Male
medicine.medical_specialty
Magnetic Resonance Spectroscopy
Phosphocreatine
Cognitive Neuroscience
Metabolite
Glycine
Glutamic Acid
Creatine
Somatosensory system
Rats, Sprague-Dawley
chemistry.chemical_compound
Internal medicine
Forelimb
medicine
Animals
Lactic Acid
biology
Chloralose
Glutamate receptor
Somatosensory Cortex
Magnetic Resonance Imaging
Electric Stimulation
Rats
Oxygen
Glutamine
Endocrinology
Neurology
chemistry
Data Interpretation, Statistical
Anesthesia, Intravenous
biology.protein
Creatine kinase
Neuroscience
Anesthetics, Intravenous
Inositol
Subjects
Details
- ISSN :
- 10538119
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- NeuroImage
- Accession number :
- edsair.doi.dedup.....e6e4e6a86a5b436840525d027337f308