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Transcriptome analysis discloses dysregulated genes in normal appearing tumor-adjacent thyroid tissues from patients with papillary thyroid carcinoma
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. The molecular characteristics of histologically normal appearing tissue adjacent to the tumor (NAT) from PTC patients are not well characterized. The aim of this study was to characterize the global gene expression profile of NAT and compare it with those of normal and tumor thyroid tissues. We performed total RNA sequencing with fresh frozen thyroid tissues from a cohort of three categories of samples including NAT, normal thyroid (N), and PTC tumor (T). Transcriptome analysis shows that NAT presents a unique gene expression profile, which was not associated with sex or the presence of lymphocytic thyroiditis. Among the differentially expressed genes (DEGs) of NAT vs N, 256 coding genes and 5 noncoding genes have been reported as cancer genes involved in cell proliferation, apoptosis, and/or tumorigenesis. Bioinformatics analysis with Ingenuity Pathway Analysis software revealed that “Cancer, Organismal Injury and Abnormalities, Cellular Response to Therapeutics, and Cellular Movement” were major dysregulated pathways in the NAT tissues. This study provides improved insight into the complexity of gene expression changes in the thyroid glands of patients with PTC.
- Subjects :
- Male
0301 basic medicine
Cell biology
endocrine system
endocrine system diseases
Carcinogenesis
Science
Thyroid Gland
Apoptosis
Pathogenesis
Biology
medicine.disease_cause
Article
Thyroid carcinoma
Transcriptome
03 medical and health sciences
0302 clinical medicine
Gene expression
Genetics
medicine
Humans
Thyroid cancer
Aged
Cell Proliferation
Multidisciplinary
Gene Expression Profiling
Thyroid
fungi
Computational Biology
Cancer
Middle Aged
Microarray Analysis
medicine.disease
Neoplasm Proteins
Gene Expression Regulation, Neoplastic
030104 developmental biology
medicine.anatomical_structure
Thyroid Cancer, Papillary
030220 oncology & carcinogenesis
Cancer research
Medicine
Female
Lymphocytic Thyroiditis
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....e6deaedc259ab9a97dd6ab730e6316d4