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Therapeutics for neonatal brain injury
- Source :
- Pharmacology & Therapeutics. 120:43-53
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Neonatal brain injury is an important cause of death and neurodevelopmental delay. Multiple pathways of oxidant stress, inflammation, and excitotoxicity lead to both early and late phases of cell damage and death. Therapies targeting these different pathways have shown potential in protecting the brain from ongoing injury. More recent therapies, such as growth factors, have demonstrated an ability to increase cell proliferation and repair over longer periods of time. Even though hypothermia, which decreases cerebral metabolism and possibly affects other mechanisms, may show some benefit in particular cases, no widely effective therapeutic interventions for human neonates exist. In this review, we summarize recent findings in neuroprotection and neurogenesis for the immature brain, including combination therapy to optimize repair.
- Subjects :
- Adult
Combination therapy
Anti-Inflammatory Agents
Ischemia
Excitotoxicity
Bioinformatics
medicine.disease_cause
Neuroprotection
Antioxidants
Hypothermia, Induced
Pregnancy
Humans
Medicine
Pharmacology (medical)
Cell damage
Neonatal stroke
Cause of death
Pharmacology
Cell Death
business.industry
Neurogenesis
Infant, Newborn
medicine.disease
Combined Modality Therapy
Brain Injuries
Anesthesia
Intercellular Signaling Peptides and Proteins
Female
business
Excitatory Amino Acid Antagonists
Stem Cell Transplantation
Subjects
Details
- ISSN :
- 01637258
- Volume :
- 120
- Database :
- OpenAIRE
- Journal :
- Pharmacology & Therapeutics
- Accession number :
- edsair.doi.dedup.....e6d7918e6a21161257e403f8dde5886d
- Full Text :
- https://doi.org/10.1016/j.pharmthera.2008.07.003