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Therapeutics for neonatal brain injury

Authors :
Fernando F. Gonzalez
Donna M. Ferriero
Source :
Pharmacology & Therapeutics. 120:43-53
Publication Year :
2008
Publisher :
Elsevier BV, 2008.

Abstract

Neonatal brain injury is an important cause of death and neurodevelopmental delay. Multiple pathways of oxidant stress, inflammation, and excitotoxicity lead to both early and late phases of cell damage and death. Therapies targeting these different pathways have shown potential in protecting the brain from ongoing injury. More recent therapies, such as growth factors, have demonstrated an ability to increase cell proliferation and repair over longer periods of time. Even though hypothermia, which decreases cerebral metabolism and possibly affects other mechanisms, may show some benefit in particular cases, no widely effective therapeutic interventions for human neonates exist. In this review, we summarize recent findings in neuroprotection and neurogenesis for the immature brain, including combination therapy to optimize repair.

Details

ISSN :
01637258
Volume :
120
Database :
OpenAIRE
Journal :
Pharmacology & Therapeutics
Accession number :
edsair.doi.dedup.....e6d7918e6a21161257e403f8dde5886d
Full Text :
https://doi.org/10.1016/j.pharmthera.2008.07.003