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Self-reported alcohol consumption, carbohydrate deficient transferrin and risk of cardiovascular disease: The PREVEND prospective cohort study
- Source :
- Kunutsor, S K, Kremer, D, Eisenga, M, Gruppen, E, de Borst, M H, Muller Kobold, A C, Kootstra-Ros, J E, Dullaart, R P F & Bakker, S J L 2021, ' Self-reported alcohol consumption, carbohydrate deficient transferrin and risk of cardiovascular disease : the PREVEND prospective cohort study ', Clinica Chimica Acta, vol. 520, pp. 1-7 . https://doi.org/10.1016/j.cca.2021.05.024, Clinica chimica acta, 520, 1-7. ELSEVIER SCIENCE BV
- Publication Year :
- 2021
-
Abstract
- Background: Self-reported alcohol consumption is an established risk factor for cardiovascular disease (CVD). Carbohydrate deficient transferrin (CDT) is an established objective marker of excessive alcohol consumption, but data on its prospective association with CVD are lacking. We aimed to evaluate the associations of self-reported alcohol consumption and CDT (expressed as %CDT, a more reliable marker than absolute CDT levels) with CVD risk.Materials and methods: In the PREVEND prospective study of 5,206 participants (mean age, 53 years; 47.7% males), alcohol consumption by self-reports, absolute CDT measured using the Siemens nephelometric assay and %CDT calculated as the percentage of total transferrin concentrations, were assessed at baseline. Alcohol consumption was classified into 5 categories: abstention (reference), light, light–moderate, moderate and heavy alcohol consumption. Hazard ratios (HRs) (95% confidence intervals [CI]) for first CVD events were estimated.Results: Mean (SD) of %CDT was 1.59 (0.54) %. During a median follow-up of 8.3 years, 326 first CVD events were recorded. Compared with abstainers, the multivariable-adjusted HRs (95% CIs) of CVD for light, light–moderate, moderate and heavy alcohol consumption were 0.66 (0.46-0.95), 0.83 (0.62-1.11), 0.83 (0.61-1.14) and 0.80 (0.48-1.36), respectively. Light alcohol consumption was associated with reduced coronary heart disease risk 0.62 (0.40-0.96), whereas light-moderate alcohol consumption was associated with reduced stroke risk 0.45 (0.24-0.83). The association of %CDT with CVD risk was not significant. Conclusions: Our findings confirm the established association between self-reported light to moderate alcohol consumption and reduced CVD risk. However, %CDT within the normal reference range may not be a risk indicator for CVD.
- Subjects :
- 0301 basic medicine
Male
Clinical Biochemistry
Alcohol
Disease
Biochemistry
Gastroenterology
CDT
chemistry.chemical_compound
0302 clinical medicine
cardiovascular disease
Prospective Studies
carbohydrate-deficient transferrin
Prospective cohort study
ASSOCIATIONS
chemistry.chemical_classification
Transferrin
General Medicine
Middle Aged
Alcoholism
risk factor
Cardiovascular Diseases
030220 oncology & carcinogenesis
Female
Alcohol consumption
medicine.medical_specialty
Alcohol Drinking
alcohol consumption
Carbohydrate deficient transferrin
Carbohydrates
GAMMA-GLUTAMYL-TRANSFERASE
FREQUENCY
03 medical and health sciences
Internal medicine
medicine
Humans
Risk factor
ABUSE
SIALIC-ACID
METAANALYSIS
business.industry
MORTALITY
Biochemistry (medical)
Confidence interval
030104 developmental biology
chemistry
Self Report
business
Biomarkers
Subjects
Details
- ISSN :
- 18733492 and 00098981
- Volume :
- 520
- Database :
- OpenAIRE
- Journal :
- Clinica chimica acta; international journal of clinical chemistry
- Accession number :
- edsair.doi.dedup.....e6c28ff178778f98178269f38e552b03