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Bone marrow biopsy in the initial staging of Ewing sarcoma: Experience from a single institution
- Publication Year :
- 2019
-
Abstract
- Background Ewing sarcoma (ES) is the second most common bone tumor in adolescents and children. Staging workup for ES includes imaging and bone marrow biopsy (BMB). The effective role of BMB is now under discussion. Procedure A monoinstitutional retrospective analysis reviewed clinical charts, imaging, and histology of patients with diagnosis of ES treated at the Rizzoli Institute between 1998 and 2017. Results The cohort included 504 cases of ES of bone; 137 (27%) had metastases at diagnosis, while the remaining 367 had localized disease. Twelve patients had a positive BMB (2.4%). Eleven had distant metastases detected at initial workup staging with imaging assessment: six patients presented with bone metastases, five with both bone and lung metastases. Only one patient with ES of the foot (second metatarsus) was found to have bone marrow involvement with negative imaging evaluation (0.3%). Conclusions On the basis of our data, we suggest reconsidering the effective role of BMB in initial staging workup for patients with ES with no signs of metastases by modern imaging techniques. In metastatic disease, the assessment of the bone marrow status may remain useful to identify a group of patients at very high risk who could benefit from different treatment strategies.
- Subjects :
- Male
Lung Neoplasms
Disease
0302 clinical medicine
Bone Marrow
Retrospective Studie
Positron Emission Tomography Computed Tomography
Single institution
Child
medicine.diagnostic_test
Hematology
Prognosis
medicine.anatomical_structure
bone marrow biopsy
Oncology
Foot Disease
030220 oncology & carcinogenesis
Child, Preschool
Cohort
Female
Radiology
Sarcoma
Human
Adult
medicine.medical_specialty
Adolescent
Prognosi
Bone Neoplasms
Sarcoma, Ewing
Bone Neoplasm
Follow-Up Studie
Foot Diseases
03 medical and health sciences
Young Adult
Biopsy
medicine
Humans
Retrospective Studies
Lung
business.industry
Infant
staging
medicine.disease
Bone Marrow Neoplasm
Lung Neoplasm
Localized disease
Pediatrics, Perinatology and Child Health
Bone marrow
business
Bone Marrow Neoplasms
Ewing sarcoma
030215 immunology
Follow-Up Studies
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....e6bfe3254da9e7df40e8e7beb9a4c4ba