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Early Stages ofwe/we wal/walMouse Hair Morphogenesis: Light and Fluorescent Microscopy of the Whole-Mount Epidermis
- Source :
- BioMed Research International, Vol 2014 (2014), BioMed Research International
- Publication Year :
- 2014
- Publisher :
- Hindawi Limited, 2014.
-
Abstract
- In adult skin, hair follicles cyclically self-renew in a manner that recapitulates embryonic hair follicle morphogenesis. The most common pathology of hair in adults is alopecia, which is hair loss to different extent. There are a number of murine models of alopecia including spontaneous mutations. In the present study, we worked with double homozygouswe/we wal/walmice which demonstrate symptoms closely resembling human alopecia. Using whole-mount preparations of epidermis of E18.5 embryos we show that hair follicle defects can be revealed as early as during embryonic morphogenesis in these mutants. The number of hair follicles was reduced almost 1.5-fold in mutant skin. The shape of the early stage small follicles was altered in mutant animals as compared to control ones. Additionally, follicles of mutant embryos were wider at the point of conjunction with interfollicular epidermis. We believe that the mutant mice studied represent a fascinating model to address the problem of hair loss. We demonstrated alterations in the morphogenesis of embryonic hair follicle inwe/we wal/waldouble homozygous mice developing alopecia postnatally. We suppose that incorrect morphogenesis of hair follicles during embryogenesis is closely related to alopecia in the adult life. Unveiling the mechanisms involved in altered embryogenesis may elucidate the pathogenesis of alopecia.
- Subjects :
- Pathology
medicine.medical_specialty
Article Subject
Mutant
Morphogenesis
Embryonic Development
lcsh:Medicine
Biology
General Biochemistry, Genetics and Molecular Biology
Mice
Embryonic morphogenesis
medicine
Animals
Humans
integumentary system
General Immunology and Microbiology
Epidermis (botany)
lcsh:R
Embryogenesis
Alopecia
Embryo
General Medicine
medicine.disease
Hair follicle
Cell biology
Hair loss
medicine.anatomical_structure
Microscopy, Fluorescence
Mutation
Epidermis
Hair Follicle
Research Article
Subjects
Details
- ISSN :
- 23146141 and 23146133
- Volume :
- 2014
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....e6b4d8bd424e4e82514d1a46282f71ac