Back to Search
Start Over
Stillbirths and neonatal deaths among 18 942 women with postpartum hemorrhage: Analysis of perinatal outcomes in the WOMAN trial
- Source :
- International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and ObstetricsREFERENCES. 153(1)
- Publication Year :
- 2020
-
Abstract
- Objective To describe the rates and risk factors for stillbirth and pre-discharge neonatal mortality (PDNM), and impact on quality of life (QoL) among women with postpartum hemorrhage (PPH). Methods A secondary analysis was conducted of the WOMAN trial, which evaluated the use of tranexamic acid for PPH and collected infant outcome data to assess drug safety. The analysis was restricted to singletons (n=18 942). Overall and country-level rates of stillbirth and PDNM were calculated. Multilevel logistic regression models examined the association of stillbirth and PDNM with selected risks, and the association of mother's QoL at discharge after stillbirth or PDNM. Results For women with PPH, the rate of stillbirths was 104.42 per 1000 births (n=1978) and the rate of PDNM was 15.56 per 1000 live births (n=264). Cesarean delivery, increasing blood loss, maternal complications, and maternal death were strongly associated with these adverse outcomes. Women with stillbirth and PDNM were significantly more likely to report poorer QoL. Conclusion Women with PPH experience an extremely high rate of stillbirth and slightly elevated PDNM, which is associated with markers of the severity of their condition and impacts on their QoL.
- Subjects :
- Adult
medicine.medical_specialty
Perinatal Death
03 medical and health sciences
Young Adult
0302 clinical medicine
Blood loss
Quality of life
Pregnancy
Risk Factors
Secondary analysis
Infant Mortality
medicine
Humans
030212 general & internal medicine
reproductive and urinary physiology
High rate
030219 obstetrics & reproductive medicine
business.industry
Neonatal mortality
Obstetrics
Cesarean Section
Postpartum Hemorrhage
Infant, Newborn
Obstetrics and Gynecology
Infant
General Medicine
Stillbirth
medicine.disease
female genital diseases and pregnancy complications
Maternal Death
Quality of Life
Maternal death
Female
Neonatal death
business
Tranexamic acid
medicine.drug
Subjects
Details
- ISSN :
- 18793479
- Volume :
- 153
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and ObstetricsREFERENCES
- Accession number :
- edsair.doi.dedup.....e6aff1ea59fadb8e9f650392c0a83511