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The recent advances in scaffolds for integrated periodontal regeneration
- Source :
- Bioactive Materials, Vol 6, Iss 10, Pp 3328-3342 (2021), Bioactive Materials
- Publication Year :
- 2021
- Publisher :
- KeAi Communications Co., Ltd., 2021.
-
Abstract
- The periodontium is an integrated, functional unit of multiple tissues surrounding and supporting the tooth, including but not limited to cementum (CM), periodontal ligament (PDL) and alveolar bone (AB). Periodontal tissues can be destructed by chronic periodontal disease, which can lead to tooth loss. In support of the treatment for periodontally diseased tooth, various biomaterials have been applied starting as a contact inhibition membrane in the guided tissue regeneration (GTR) that is the current gold standard in dental clinic. Recently, various biomaterials have been prepared in a form of tissue engineering scaffold to facilitate the regeneration of damaged periodontal tissues. From a physical substrate to support healing of a single type of periodontal tissue to multi-phase/bioactive scaffold system to guide an integrated regeneration of periodontium, technologies for scaffold fabrication have emerged in last years. This review covers the recent advancements in development of scaffolds designed for periodontal tissue regeneration and their efficacy tested in vitro and in vivo. Pros and Cons of different biomaterials and design parameters implemented for periodontal tissue regeneration are also discussed, including future perspectives.<br />Graphical abstract Image 1<br />Highlights • Periodontal diseases are a major cause of tooth loss and the current treatment suffers from limitations. • Biomaterial scaffold-guided regeneration of periodontal tissues have recently emerged. • This review addresses the recent advance in bioactive scaffold for integrated regeneration of multiple periodontal tissues. • The outstanding limitations and future perspectives are also discussed.
- Subjects :
- Periodontium
QH301-705.5
0206 medical engineering
Biomedical Engineering
Dentistry
02 engineering and technology
Article
Biomaterials
stomatognathic system
Multi-phase scaffold
Tooth loss
Periodontal fiber
Medicine
Cementum
Biology (General)
Periodontitis
Materials of engineering and construction. Mechanics of materials
Dental alveolus
Bioactive scaffold
business.industry
Periodontal regeneration
Regeneration (biology)
021001 nanoscience & nanotechnology
medicine.disease
020601 biomedical engineering
stomatognathic diseases
medicine.anatomical_structure
TA401-492
medicine.symptom
0210 nano-technology
business
Biotechnology
Subjects
Details
- Language :
- English
- Volume :
- 6
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Bioactive Materials
- Accession number :
- edsair.doi.dedup.....e68fa7cbf682516afa68c6e4195d6ea5