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Biomarkers of tolerance: searching for the hidden phenotype
- Source :
- Kidney International Supplements
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Induction of transplantation tolerance remains the ideal long-term clinical and logistic solution to the current challenges facing the management of renal allograft recipients. In this review, we describe the recent studies and advances made in identifying biomarkers of renal transplant tolerance, from study inceptions, to the lessons learned and their implications for current and future studies with the same goal. With the age of biomarker discovery entering a new dimension of high-throughput technologies, here we also review the current approaches, developments, and pitfalls faced in the subsequent statistical analysis required to identify valid biomarker candidates.
- Subjects :
- validation
medicine.medical_specialty
Pathology
Future studies
tolerance
business.industry
immunosupression
biomarkers
Meeting Report
renal transplantation
Transplantation
Nephrology
Renal transplant
Valid Biomarker
Renal allograft
Medicine
Statistical analysis
Biomarker discovery
business
Intensive care medicine
Subjects
Details
- ISSN :
- 21571716
- Volume :
- 1
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Kidney International Supplements
- Accession number :
- edsair.doi.dedup.....e68afc12000c76ffedb08b941ba79a4c
- Full Text :
- https://doi.org/10.1038/kisup.2011.11