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Hematological and Genetic Markers in the Rational Approach to Patients With HCV Sustained Virological Response With or Without Persisting Cryoglobulinemic Vasculitis
- Source :
- Hepatology (Baltimore, Md.)
- Publication Year :
- 2021
-
Abstract
- Background and Aims Direct‐acting antivirals (DAAs) usually lead to improvement/remission of cryoglobulinemic vasculitis (CV), although symptoms may persist/recur after a sustained virological response (SVR). We evaluated hematological and genetic markers in patients with HCV‐SVR vasculitis with and without persisting/recurring symptoms to early predict the CV outcome. Approach and Results Ninety‐eight patients with HCV‐CV were prospectively enrolled after a DAA‐induced SVR: Group A: 52 with complete clinical response; Group B: 46 with symptom maintenance/recurrence. Monoclonal B‐cell lymphocytosis, t(14;18) translocation, and abnormal free light chains κ/λ ratios were detected by flow cytometry or nested‐PCR or nephelometry in 4% Group A versus 17% Group B (P = 0.04) patients, 17% Group A versus 40% Group B patients (P = 0.02), and 17% Group A versus 47% Group B (P = 0.003) patients, respectively. At least 1 out of 3 clonality markers was altered/positive in 29% of Group A versus 70% of Group B patients (P
- Subjects :
- Male
Vasculitis
0301 basic medicine
medicine.medical_specialty
Sustained Virologic Response
Lymphocytosis
Viral Hepatitis
Chromosomal translocation
Antiviral Agents
Polymorphism, Single Nucleotide
Gastroenterology
Group A
Translocation, Genetic
Group B
Immunoglobulin kappa-Chains
03 medical and health sciences
0302 clinical medicine
Immunoglobulin lambda-Chains
Recurrence
Internal medicine
Genotype
medicine
Humans
Receptor, Notch4
Cryoglobulinemic vasculitis
Aged
DAA
Chromosomes, Human, Pair 14
Hepatology
business.industry
Original Articles
Hepatitis C, Chronic
Middle Aged
Prognosis
medicine.disease
030104 developmental biology
Cryoglobulinemia
HCV
genetic markers
cryoglobulinemic vasculitis
Monoclonal
Female
Original Article
030211 gastroenterology & hepatology
medicine.symptom
Chromosomes, Human, Pair 18
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Hepatology (Baltimore, Md.)
- Accession number :
- edsair.doi.dedup.....e688966a7dfdebfb0db956d64987d684