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Screening for potential familial hypercholesterolaemia in general practice: an observational study on prevalence and management
- Source :
- BJGP Open, BJGP Open, Vol 5, Iss 2 (2021), Mülverstedt, S, Hildebrandt, P R, Prescott, E & Heitmann, M 2021, ' Screening for Potential Familial Hypercholesterolaemia in General Practice : an Observational Study on Prevalence and Management ', BJGP Open, vol. 5, no. 2, pp. 1-13 . https://doi.org/10.3399/bjgpopen20X101142
- Publication Year :
- 2021
- Publisher :
- Royal College of General Practitioners, 2021.
-
Abstract
- BackgroundFamilial hypercholesterolaemia (FH) is a common genetic disorder causing premature cardiovascular disease (CVD). The estimated prevalence of probable or definite FH is 1:200–250 individuals, according to the Dutch Lipid Clinic Network (DLCN) criteria for FH. In Denmark approximately 12% of cases are identified.AimTo provide knowledge of the prevalence and management of FH in general practice.Design & settingA collaboration between six general practice clinics and the department of cardiology at Bispebjerg hospital in Denmark.MethodA total of 9652 patient records were screened for hypercholesterolaemia. All patients with a low-density lipoprotein cholesterol (LDL-C) ≥5.0 mmol/l were included in the study population and their records were investigated in order to perform a diagnostic score according to the DLCN criteria.ResultsIt was found that 2382 individuals had a lipid measurement available, and 236 of those had an LDL-C ≥5.0 mmol/l. In total, 34 individuals were found to have probable or definite FH (DLCN score ≥5). Only three individuals had been diagnosed and treated with lipid-lowering therapy. Of 236 individuals with high LDL-C, only 25 individuals met their treatment target. By excluding patients with signs of secondary hypercholesterolaemia, a subgroup of 115 individuals with potential primary hypercholesterolaemia was established. Among those, 21 individuals were found to have probable or definite FH (1:114 individuals).ConclusionThe study shows that there is a massive lack of recognition of FH in general practice. Despite a measured high LDL-C, the diagnosis is rarely made and only a few patients are treated accordingly. Of the patients undergoing treatment, only a few reached their treatment target.
- Subjects :
- mass screening
Pediatrics
medicine.medical_specialty
Medicine (General)
Disease
030204 cardiovascular system & hematology
Primary hypercholesterolaemia
03 medical and health sciences
0302 clinical medicine
R5-920
lipid lowering therapy
Medicine
030212 general & internal medicine
Lipid clinic
Mass screening
Lipoprotein cholesterol
general practice
business.industry
Research
cardiovascular diseases
General practice
familial hypercholesterolaemia
Population study
Observational study
lipids (amino acids, peptides, and proteins)
Family Practice
business
Subjects
Details
- Language :
- English
- ISSN :
- 23983795
- Volume :
- 5
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- BJGP Open
- Accession number :
- edsair.doi.dedup.....e6771ee5e68959d61514cc9ffecc96ab