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Effect of cannabis use on the course of schizophrenia in male patients: A prospective cohort study
- Source :
- Schizophrenia research, 137(1-3), 50-57. Elsevier
- Publication Year :
- 2012
-
Abstract
- Background: Findings on the impact of cannabis use on the course of schizophrenia are inconsistent and not conclusive. Aims: To study the effect of cannabis use on the course of schizophrenia taking into account the effects of the quantity of cannabis use and important confounders. Methods: Prospective cohort study with assessments of symptoms, confounders and hospitalizations at baseline, 6 month and 12 month follow up. Results: In a representative cohort of 145 male patients with schizophrenia, 68 (46.9%) used cannabis. Mean age at onset of schizophrenia in cannabis using patients was significantly lower than in non-cannabis using patients. No other cross-sectional demographic or clinical differences were observed between users and non-users. In a series of longitudinal analyses, cannabis use was not associated with differences in psychopathology, but relapse in terms of the number of hospitalizations was significantly higher in cannabis using patients compared to non-cannabis using patients. Conclusions: Patients with schizophrenia using cannabis are more frequently hospitalized than non-cannabis using patients but do not differ with respect to psychopathology. Possible explanations for these findings are discussed. (C) 2012 Elsevier B.V. All rights reserved
- Subjects :
- Adult
Male
Marijuana Abuse
medicine.medical_specialty
Adolescent
Cohort Studies
Young Adult
Quality of life
medicine
Humans
Young adult
Prospective cohort study
Psychiatry
Biological Psychiatry
Aged
Demography
Netherlands
Psychiatric Status Rating Scales
biology
Middle Aged
medicine.disease
biology.organism_classification
Psychiatry and Mental health
Schizophrenia
Cohort
Quality of Life
Regression Analysis
Schizophrenic Psychology
Cannabis
Psychology
Psychopathology
Clinical psychology
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 09209964
- Database :
- OpenAIRE
- Journal :
- Schizophrenia research, 137(1-3), 50-57. Elsevier
- Accession number :
- edsair.doi.dedup.....e671b1cff6e3f5c5f47b0e5efab931fd