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Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years
- Source :
- J Neurosci Res
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Over the last 10 years, rates of alcohol use disorder (AUD) have increased in women by 84% relative to a 35% increase in men. Rates of alcohol use and high-risk drinking have also increased in women by 16% and 58% relative to a 7% and 16% increase in men, respectively, over the last decade. This robust increase in drinking among women highlights the critical need to identify underlying neural mechanisms that may contribute to problematic alcohol consumption across sex/gender (SG), especially given that many neuroimaging studies are underpowered to detect main or interactive effects of SG on imaging outcomes. This narrative review aims to explore the recent neuroimaging literature on SG differences in brain function and structure as it pertains to alcohol across positron emission tomography (PET), magnetic resonance imaging (MRI), and functional magnetic resonance imaging (fMRI) modalities in humans. Additional work using magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI), and event-related potentials (ERPs) to examine SG differences in AUD will be covered. Overall, current research neuroimaging AUD, alcohol consumption, or risk of AUD is limited, and findings are mixed regarding the effect of SG on neurochemical, structural, and functional mechanisms associated with AUD. We address SG disparities in the neuroimaging of AUD and propose a call to action to include women in brain imaging research. Future studies are crucial to our understanding of the neurobiological underpinnings of AUD across neural systems and the vulnerability for AUD among women and men.
- Subjects :
- Male
0301 basic medicine
Poison control
Neuroimaging
Alcohol use disorder
Article
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
mental disorders
Injury prevention
Humans
Medicine
Sex Characteristics
Modalities
medicine.diagnostic_test
business.industry
Brain
Human factors and ergonomics
Magnetic resonance imaging
medicine.disease
Alcoholism
030104 developmental biology
Female
business
Functional magnetic resonance imaging
030217 neurology & neurosurgery
Clinical psychology
Subjects
Details
- ISSN :
- 10974547 and 03604012
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- Journal of Neuroscience Research
- Accession number :
- edsair.doi.dedup.....e6563a886e8d74cfaf42d053226b23de