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Reduction of Immune System Activation in HIV-1-Infected Patients Undergoing Highly Active Antiretroviral Therapy
- Source :
- Scopus-Elsevier
- Publication Year :
- 1999
- Publisher :
- Springer Science and Business Media LLC, 1999.
-
Abstract
- The aim of this work was to analyze the effects of highly active antiretroviral therapy on the chronically activated immune system of 26 antiretroviral-naive HIV-1-infected patients. Samples from baseline to week 24 or 36 of treatment were tested for serum levels of beta2-microglobulin, tumor necrosis factor alpha and soluble tumor necrosis factor alpha receptor type II, as well as for human leukocyte antigen-DR expression on T cells. After starting therapy, the mean HIV-1 RNA serum levels decreased and the mean CD4 + cell counts increased from baseline to week 36 (P0.001). Mean levels of tumor necrosis factor alpha receptor type II, tumor necrosis factor alpha and beta2-microglobulin as well as expression of human leukocyte antigen-DR were significantly reduced at the end of follow-up (P0.01). Deactivation kinetics of these parameters was similar in patients with CD4+ counts200 cells/microl at baseline versus those with CD4 + counts200 cells/microl at baseline, despite higher activation at baseline in the group with200 cells/microl. In summary, this study shows that highly active antiretroviral therapy is able to induce a strong deactivation of the immune system of HIV-1-infected patients.
- Subjects :
- Adult
Male
Microbiology (medical)
Anti-HIV Agents
medicine.medical_treatment
Receptors, Tumor Necrosis Factor
Immune system
Antigen
Antigens, CD
Immunity
Immunopathology
medicine
Humans
Receptors, Tumor Necrosis Factor, Type II
Acquired Immunodeficiency Syndrome
Chemotherapy
biology
Tumor Necrosis Factor-alpha
Beta-2 microglobulin
HLA-DR Antigens
General Medicine
biology.organism_classification
Infectious Diseases
Cytokine
Lentivirus
Immunology
HIV-1
Female
beta 2-Microglobulin
Subjects
Details
- ISSN :
- 14354373 and 09349723
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- European Journal of Clinical Microbiology & Infectious Diseases
- Accession number :
- edsair.doi.dedup.....e64943e0e1ca3ded70e7bdbde8fdfb6f
- Full Text :
- https://doi.org/10.1007/s100960050388