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Reduction of Immune System Activation in HIV-1-Infected Patients Undergoing Highly Active Antiretroviral Therapy

Authors :
Juan Macías
Antonio Núñez-Roldán
Miguel C. Leal
B. Sánchez
Eduardo Lissen
C. Rey
Amalia Rubio
Armando Sánchez-Quijano
Juan A. Pineda
Jaime M. Franco
Source :
Scopus-Elsevier
Publication Year :
1999
Publisher :
Springer Science and Business Media LLC, 1999.

Abstract

The aim of this work was to analyze the effects of highly active antiretroviral therapy on the chronically activated immune system of 26 antiretroviral-naive HIV-1-infected patients. Samples from baseline to week 24 or 36 of treatment were tested for serum levels of beta2-microglobulin, tumor necrosis factor alpha and soluble tumor necrosis factor alpha receptor type II, as well as for human leukocyte antigen-DR expression on T cells. After starting therapy, the mean HIV-1 RNA serum levels decreased and the mean CD4 + cell counts increased from baseline to week 36 (P0.001). Mean levels of tumor necrosis factor alpha receptor type II, tumor necrosis factor alpha and beta2-microglobulin as well as expression of human leukocyte antigen-DR were significantly reduced at the end of follow-up (P0.01). Deactivation kinetics of these parameters was similar in patients with CD4+ counts200 cells/microl at baseline versus those with CD4 + counts200 cells/microl at baseline, despite higher activation at baseline in the group with200 cells/microl. In summary, this study shows that highly active antiretroviral therapy is able to induce a strong deactivation of the immune system of HIV-1-infected patients.

Details

ISSN :
14354373 and 09349723
Volume :
18
Database :
OpenAIRE
Journal :
European Journal of Clinical Microbiology & Infectious Diseases
Accession number :
edsair.doi.dedup.....e64943e0e1ca3ded70e7bdbde8fdfb6f
Full Text :
https://doi.org/10.1007/s100960050388