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Fluconazole and itraconazole susceptibility of vaginal yeast isolates from Slovakia
- Source :
- Mycopathologia. 157:163-169
- Publication Year :
- 2004
- Publisher :
- Springer Science and Business Media LLC, 2004.
-
Abstract
- Vulvovaginal candidiasis is a common mucosal infection caused by opportunistic yeasts of the Candida genus. In this study, we isolated and identified the yeast species in the vagina of patients treated in the gynecology clinic and tested in vitro activities of fluconazole and itraconazole against 227 clinical yeast isolates by the NCCLS microdilution method. C. albicans (87.6%) was the most frequently identified species followed by C. glabrata (6.2%) and C. krusei (2.2%). Almost thirteen percent of yeast strains were resistant to fluconazole and 18.5% were resistant to itraconazole. Cross-resistance analyses of C. albicans isolates revealed that fluconazole resistance and itraconazole resistance were also associated with decreased susceptibilities to other azole derivatives mainly to ketoconazole and miconazole. At the same time no cross-resistance to polyene antibiotics amphotericin B and nystatin was observed. These results support the notion that antifungal agents used to treat vaginitis may be contributing to the drug resistance problem by promoting cross-resistance to a range of clinically used antifungals.
- Subjects :
- Antifungal Agents
Itraconazole
Veterinary (miscellaneous)
Candida glabrata
Microbial Sensitivity Tests
Applied Microbiology and Biotechnology
Microbiology
Drug Resistance, Fungal
Amphotericin B
Candida albicans
medicine
Humans
Fluconazole
Candidiasis, Vulvovaginal
Candida
chemistry.chemical_classification
biology
business.industry
biology.organism_classification
Nystatin
chemistry
Vagina
Azole
Female
Ketoconazole
Miconazole
business
Agronomy and Crop Science
medicine.drug
Subjects
Details
- ISSN :
- 0301486X
- Volume :
- 157
- Database :
- OpenAIRE
- Journal :
- Mycopathologia
- Accession number :
- edsair.doi.dedup.....e63f8db001269459cc5a0d16244a50e6