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Theacrine, a purine alkaloid with anti-inflammatory and analgesic activities
- Source :
- Fitoterapia. 81(6)
- Publication Year :
- 2010
-
Abstract
- The anti-inflammatory and analgesic effects of theacrine (1, 3, 7, 9-tetramethyluric acid), a purine alkaloid which is abundantly present in Camellia kucha, were investigated. Xylene-induced ear edema, acetic acid-induced vascular permeability and lambda-carrageenan-induced paw edema were used to investigate anti-inflammatory activity, and acetic acid-induced writhing and hot-plate tests were used to determine analgesic effect. Oral administration of theacrine (8-32 mg/kg) induced dose-related anti-inflammatory and analgesic effects. On the other hand, oral caffeine administration (8-32 mg/kg) did not show an inhibitory effect on the inhibition of inflammatory response or cause analgesia. Additionally, the result of the acute toxicity test showed that the LD(50) of theacrine was 810.6 mg/kg (769.5-858.0mg/kg). The data obtained suggest theacrine possessed analgesic and anti-inflammatory activities.
- Subjects :
- Male
medicine.drug_class
Analgesic
Anti-Inflammatory Agents
Drug Evaluation, Preclinical
Pain
Pharmacology
Anti-inflammatory
law.invention
chemistry.chemical_compound
Mice
law
Oral administration
Drug Discovery
medicine
Animals
Theacrine
Inflammation
Analgesics
Plant Extracts
Alkaloid
Camellia
General Medicine
Acute toxicity
Uric Acid
chemistry
Female
Phytotherapy
Caffeine
Subjects
Details
- ISSN :
- 18736971
- Volume :
- 81
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Fitoterapia
- Accession number :
- edsair.doi.dedup.....e6321f088406efff224aba449188dbdd