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Aptamers that bind to the antibiotic moenomycin A
- Source :
- Bioorganic & Medicinal Chemistry. 9:2557-2563
- Publication Year :
- 2001
- Publisher :
- Elsevier BV, 2001.
-
Abstract
- Nuclease-resistant moenomycin-binding aptamers with dissociation constants in the range of 300 to 400 nM have been selected. Competition experiments have demonstrated that these aptamers recognize a disaccharide analogue of moenomycin. The results offer the opportunity of setting up a selective and sensitive assay for identifying moenomycin biosynthetic precursors.
- Subjects :
- medicine.drug_class
Aptamer
Molecular Sequence Data
Clinical Biochemistry
Antibiotics
Oligonucleotides
Disaccharide
Pharmaceutical Science
Microbial Sensitivity Tests
Disaccharides
Biochemistry
chemistry.chemical_compound
Drug Discovery
medicine
Combinatorial Chemistry Techniques
Molecular Biology
Chromatography, High Pressure Liquid
Antibacterial agent
Bacteriological Techniques
Nuclease
Bacteria
Base Sequence
Molecular Structure
biology
Sequence Analysis, RNA
Moenomycin A
Chemistry
Organic Chemistry
Drug Resistance, Microbial
DNA
Ligand (biochemistry)
Anti-Bacterial Agents
Dissociation constant
Bambermycins
biology.protein
RNA
Molecular Medicine
Subjects
Details
- ISSN :
- 09680896
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....e6226ccbd089d2c7df525dbdc149ade7