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Neuroprotective effects of curcumin lipid-core nanocapsules in a model Alzheimer’s disease induced by β-amyloid 1-42 peptide in aged female mice
- Source :
- Brain Research. 1721:146325
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Alzheimer's disease (AD) is a progressive neurodegenerative disease and the most common form of dementia, representing about 60–70% of cases. Curcumin is a natural compound extracted from Curcuma longa Linn, widely used in cooking, presenting several biological activities, including neuroprotection. However, it has low solubility and consequently its bioavailability is limited. In recent years, researchers have focused their attention on delivery systems based on nanotechnology because of their promising potential and advantages over conventional approaches. This study investigated the neuroprotective effects of curcumin loaded lipid-core nanocapsules (LNC) in a model of Alzheimer’s disease (AD) induced by intracerebroventricular injections of β-amyloid1-42 (Aβ1-42) peptide in aged female mice, and compared these effects with those from free curcumin. Aged female mice received curcumin, free (50 mg/kg, p.o.) or loaded nanocapsules (10 or 1 mg/kg, p.o.) for 14 days after Aβ1-42 administration. Aβ1-42 induced significant cognitive deficit (Morris Water Maze test), as well as caused increased the levels of inflammatory cytokines in prefrontal cortex, hippocampus and serum of mice. LNC displayed significant neuroprotection against Aβ1-42-induced behavioral and neurochemical changes in a model of AD. These results provide insights into the neuroprotective actions of curcumin and its nanoencapsulation as a promising approach for application as an neuroprotective agent in the prevention of AD.
- Subjects :
- 0301 basic medicine
Curcumin
Morris water navigation task
Hippocampus
Pharmacology
Neuroprotection
Nanocapsules
Proinflammatory cytokine
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Neurochemical
Alzheimer Disease
medicine
Animals
Cognitive Dysfunction
Molecular Biology
Cognitive deficit
Amyloid beta-Peptides
business.industry
General Neuroscience
Brain
Neurodegenerative Diseases
Lipids
Disease Models, Animal
Neuroprotective Agents
030104 developmental biology
chemistry
Female
Neurology (clinical)
medicine.symptom
Cognition Disorders
business
030217 neurology & neurosurgery
Developmental Biology
Subjects
Details
- ISSN :
- 00068993
- Volume :
- 1721
- Database :
- OpenAIRE
- Journal :
- Brain Research
- Accession number :
- edsair.doi.dedup.....e611a45895d6e7832b20c4a5c6ddc4e1