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Single nuclear gene inherited cross resistance and collateral sensitivity to 17 inhibitors of mitochondrial function in S. cerevisiae
- Source :
- Moleculargeneral genetics : MGG. 126(2)
- Publication Year :
- 1973
-
Abstract
- Previous tetrad analyses defined a yeast strain (332-7c) as containing a single nuclear gene (11.8 map units from the centromere) conferring resistance to oligomycin. Resistance to 18 additional inhibitors of mitochondrial function (Table 1) was determined on (i) ascospore isolates from tetrads segregating 2 resistant: 2 sensitive for oligomycin (Table 2) and (ii), spontaneously derived sensitive isolates of the oligomycin resistant strain (Tables 3 and 4). The observed pattern of resistance suggests that the gene for resistance to oligomycin also results in (i) cross resistance to rutamycin, venturicidin, triethyltin bromide, antimycin A, carbonylcyanide m-chlorophenylhydrazone, tetra-N-butylammonium bromide, dibenzyl-dimethylammonium chlorop and tetracycline and (ii), collateral sensitivity to paromomycin, neomycin, dequalinium chloride, ethidium bromide and acriflavin.
- Subjects :
- Oligomycin
Nuclear gene
Antifungal Agents
Genotype
Antimycin A
Saccharomyces cerevisiae
Biology
Cross Reactions
Oxidative Phosphorylation
chemistry.chemical_compound
Bromide
Genetics
medicine
Molecular Biology
Cross-resistance
Venturicidin
Uncoupling Agents
fungi
Chromosome Mapping
Drug Resistance, Microbial
Neomycin
Mitochondria
Quaternary Ammonium Compounds
Chloramphenicol
Phenotype
chemistry
Biochemistry
Genes
Oligomycins
Ethidium bromide
medicine.drug
Subjects
Details
- ISSN :
- 00268925
- Volume :
- 126
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Moleculargeneral genetics : MGG
- Accession number :
- edsair.doi.dedup.....e60ddd04d1b740c0632e88de064c9856