Back to Search
Start Over
Immunohistochemical Validation of Spontaneously Arising Canine Osteosarcoma as a Model for Human Osteosarcoma
- Source :
- Journal of comparative pathology. 157(4)
- Publication Year :
- 2017
-
Abstract
- Osteosarcoma (OS) originates from bone-forming mesenchymal cells and represents one of the primary bone tumours. It is the most common primary bone tumour in dogs and man. The characterization of an appropriate natural disease animal model to study human OS is essential to elucidate the pathogenesis of the disease. This study aimed to validate canine OS as a model for the human disease by evaluating immunohistochemically the expression of markers known to be important in human OS. The immunohistochemical panel included vimentin, alkaline phosphatase (ALP), desmin, S100, neuron-specific enolase (NSE), runt-related transcription factor 2 (Runx2) and bone morphogenetic protein 4 (BMP4). Immunohistochemistry was conducted on formalin-fixed, paraffin wax-embedded tissue sections from 59 dogs with confirmed primary OS. Vimentin, ALP, Runx2 and BMP4 were highly expressed by all tumours, while desmin, S100 and NSE were expressed variably. The findings were similar to those described previously for human OS and suggest that canine OS may represent a useful model for the study of the human disease.
- Subjects :
- Pathology
medicine.medical_specialty
040301 veterinary sciences
Vimentin
Bone Neoplasms
Pilot Projects
Bone morphogenetic protein
Canine Osteosarcoma
Pathology and Forensic Medicine
0403 veterinary science
03 medical and health sciences
0302 clinical medicine
Dogs
medicine
Biomarkers, Tumor
Animals
Humans
Osteosarcoma
General Veterinary
biology
04 agricultural and veterinary sciences
medicine.disease
Disease Models, Animal
Primary bone
Bone morphogenetic protein 4
030220 oncology & carcinogenesis
biology.protein
Immunohistochemistry
Desmin
Subjects
Details
- ISSN :
- 15323129
- Volume :
- 157
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of comparative pathology
- Accession number :
- edsair.doi.dedup.....e60a30fa746068f6809c56848babf28a