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Rendimiento diagnóstico de marcadores tumorales séricos convencionales en pacientes con sospecha clínica de cáncer primario metastásico a hígado
- Source :
- Revista médica de Chile v.146 n.12 2018, SciELO Chile, CONICYT Chile, instacron:CONICYT
- Publication Year :
- 2018
- Publisher :
- SciELO Agencia Nacional de Investigacion y Desarrollo (ANID), 2018.
-
Abstract
- Background: Conventional serum tumor markers (CSTM) are widely used for monitoring patients with cancer. However, their usefulness as a diagnostic tool is controversial in primary or metastatic liver cancer (PMLC). Aim: To evaluate the diagnostic performance of the most commonly requested CSTM in the diagnostic approach of PMLC. Material and Methods: Review of medical records of patients aged over 18 years with a liver biopsy, attended from 2005 to 2017 in a tertiary hospital and a regional cancer center in Colombia. The results of liver biopsies were compared with tumor markers such as carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), CA 19-9, CA 125 and prostate specific antigen (PSA) using a receiver operating characteristic (ROC) curve analysis. Results: We reviewed 2063 medical records and retrieved 118 eligible patients (59 cases and 59 controls, 70% males). Thirty percent had obstructive jaundice. There was heterogeneity in the amount of tumor markers requested according to medical criteria. Only CA 19-9 showed discriminative capacity (> 17.6 U/m), with a cut-off point lower than that reported in the literature and a sensitivity of 69.5%, specificity of 91.6%, a positive likelihood ratio (LR) of 8.32, and a negative LR of 0.33. Conclusions: Except for CA 19-9, tumor markers were not useful for the initial diagnostic approach in patients with suspected primary or metastatic malignant liver tumors.
- Subjects :
- medicine.medical_specialty
medicine.diagnostic_test
Receiver operating characteristic
biology
business.industry
Liver Neoplasms
Cancer
General Medicine
medicine.disease
Gastroenterology
Likelihood ratios in diagnostic testing
Metastasis
Prostate-specific antigen
Carcinoembryonic antigen
Internal medicine
Liver biopsy
Predictive value of tests
Biomarkers, Tumor
medicine
biology.protein
Mass Screening
business
Subjects
Details
- ISSN :
- 00349887
- Volume :
- 146
- Database :
- OpenAIRE
- Journal :
- Revista médica de Chile
- Accession number :
- edsair.doi.dedup.....e608aa7f0339c78044d12cc0b8fafac9