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Oral contraceptive use and breast or ovarian cancer risk in BRCA1/2 carriers: A meta-analysis
- Source :
- European Journal of Cancer. 46:2275-2284
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- Women with BRCA1 or BRCA2 mutations are at increased risk of breast and ovarian cancer. Oral contraceptives (OC) use has been associated with a reduction in ovarian cancer risk and with a moderately increased breast cancer risk, which tends to level off in the few years after stopping. The association between oral contraceptive and BRCA1 or BRCA2 gene mutations carriers is unclear.We performed a comprehensive literature search updated to March 2010 of studies on the associations between OC users and breast or ovarian cancer for ascertained BRCA1/2 carriers. We obtained summary risk estimated for ever OC users, for duration of use and time since stopping.A total of 2855 breast cancer cases and 1503 ovarian cancer cases, carrying an ascertained BRCA1/2 mutation, were included in our meta-analyses, based on overall 18 studies. Use of OC was associated with a significant reduced risk of ovarian cancer for BRCA1/2 carriers (summary relative risk (SRR)=0.50; 95% confidence interval (CI), 0.33-0.75). We also observed a significant 36% risk reduction for each additional 10 years of OC use (SRR: 0.64; 95% CI, 0.53-0.78; P trend0.01). We found no evidence of a significant association between OC and breast cancer risk in carriers (SRR: 1.13; 95% CI, 0.88-1.45) and with duration of use. OC formulations used before 1975 were associated with a significant increased risk of breast cancer (SRR: 1.47; 95% 1.06, 2.04), but no evidence of a significant association was found with use of more recent formulations (SRR: 1.17; 95% 0.74, 1.86).OC users carrying an ascertained BRCA1/2 mutation have a reduced risk of ovarian cancer, proportional to the duration of use. There is no evidence that recent OC formulations increase breast cancer risk in carriers.
- Subjects :
- Adult
Oncology
Heterozygote
Cancer Research
medicine.medical_specialty
Adolescent
endocrine system diseases
Genes, BRCA2
Genes, BRCA1
Breast Neoplasms
Gene mutation
Risk Assessment
Breast cancer
Risk Factors
Internal medicine
Humans
Medicine
Risk factor
skin and connective tissue diseases
Ovarian Neoplasms
Gynecology
business.industry
Cancer
medicine.disease
Relative risk
Mutation
Female
Breast disease
business
Risk assessment
Ovarian cancer
Contraceptives, Oral
Subjects
Details
- ISSN :
- 09598049
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- European Journal of Cancer
- Accession number :
- edsair.doi.dedup.....e600926fe91ea994133c840aa1b2e8ed