Experimental contact sensitization with 3,4,5-trichloropyridazine

The potential of 3,4,5-trichloropyridazine to induce contact sensitization was assessed in the guinea pig maximization test of Magnusson and Kligman and also in the closed patch test described by Buehler. The lest material was a 1% solution of 3,4,5-triehloropyridnzine in a highly refined mineral oil. The lest material elicited moderate to severe irritation when diluted in mineral oil to concentrations of 15–25% and minimal irritation at concentrations of 1–3%. Both tests dearly indicated that 3,4,5-trichloropyridazine was a contact sensitization to guinea pigs, although the response was stronger in the maximization lest Sensitization was distinguished from irritation by the use of concurrent irritation control groups.