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Preoperative Magnetic Resonance Imaging in Patients With Stage I Invasive Ductal Breast Cancer: A Prospective Randomized Study
- Source :
- ResearcherID
- Publication Year :
- 2017
- Publisher :
- SAGE Publications, 2017.
-
Abstract
- Background and Aims: Preoperative magnetic resonance imaging has become an important complementary imaging technique in patients with breast cancer, providing additional information for preoperative local staging. Magnetic resonance imaging is recommended selectively in lobular breast cancer and in patients with dense breast tissue in the case when mammography and ultrasound fail to fully evaluate the lesion, but the routine use of magnetic resonance imaging in all patients with invasive ductal carcinoma is controversial. The purpose of this randomized study was to investigate the diagnostic value of preoperative magnetic resonance imaging and its impact on short-term surgical outcome in newly diagnosed unifocal stage I invasive ductal carcinoma. Material and Methods: A total of 100 patients were randomized to either receive preoperative breast magnetic resonance imaging or to be scheduled directly to operation without magnetic resonance imaging on a 1:1 basis. There were 50 patients in both study arms. Results: In 14 patients (28%), breast magnetic resonance imaging detected an additional finding and seven of them were found to be malignant. Six additional cancer foci were found in the ipsilateral breast and one in the contralateral breast. Magnetic resonance imaging findings caused a change in planned surgical management in 10 patients (20%). Mastectomy was performed in six patients (12%) in the magnetic resonance imaging group and in two patients (4%) in the control group ( p = 0.140). The breast reoperation rate was 14% in the magnetic resonance imaging group and 24% in the control group ( p = 0.202). The mean interval between referral and first surgical procedure was 34 days in the magnetic resonance imaging group and 21 days in the control group ( p Conclusion: Preoperative magnetic resonance imaging may be beneficial for some patients with early-stage invasive ductal carcinoma, but its routine use is not recommended without specific indications.
- Subjects :
- Cancer Research
medicine.medical_treatment
Mastectomy, Segmental
030218 nuclear medicine & medical imaging
law.invention
Hospitals, University
0302 clinical medicine
Randomized controlled trial
law
Breast-conserving surgery
Prospective randomized study
Prospective Studies
skin and connective tissue diseases
Finland
Aged, 80 and over
medicine.diagnostic_test
Biopsy, Needle
Carcinoma, Ductal, Breast
Ultrasound
Middle Aged
Prognosis
Immunohistochemistry
Magnetic Resonance Imaging
Invasive ductal breast cancer
Treatment Outcome
Oncology
030220 oncology & carcinogenesis
Female
Radiology
Mastectomy
medicine.medical_specialty
Breast Neoplasms
Risk Assessment
Disease-Free Survival
Statistics, Nonparametric
03 medical and health sciences
Breast cancer
Preoperative Care
medicine
Humans
Mammography
In patient
Aged
ta3126
business.industry
Magnetic resonance imaging
ta3122
equipment and supplies
medicine.disease
Survival Analysis
Surgery
Neoplasm Recurrence, Local
business
human activities
Subjects
Details
- ISSN :
- 17997267 and 14574969
- Volume :
- 107
- Database :
- OpenAIRE
- Journal :
- Scandinavian Journal of Surgery
- Accession number :
- edsair.doi.dedup.....e5f20cc6f3b6bd0bbdab87f361ce41a2