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Melanocytic Nevi of the Tarsal Conjunctiva: Clinicopathologic Case Series With Review of Literature
- Source :
- Ophthalmic Plastic & Reconstructive Surgery. 26:438-442
- Publication Year :
- 2010
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2010.
-
Abstract
- Purpose To describe 4 patients with histopathologically confirmed tarsal conjunctival nevi and to review the literature regarding nevi in this location. Methods Clinicopathologic series of 4 cases diagnosed at the New York Eye and Ear Infirmary between January 1990 and April 2009. PubMed was searched for reported cases of tarsal conjunctival nevi. Results Four patients (mean age 44 years, median 50 years, range 5-70 years) with tarsal conjunctival nevi were identified (3.4% of all histopathologically diagnosed conjunctival nevi). These lesions presented in adulthood (3 cases) and were associated with elevation/nodularity (3 cases), gray-brown coloration (3 cases), physician-documented growth (1 case), madarosis (1 case), and intrinsic vessels (1 case). Histopathology revealed combined nevi centered in the posterior lamella of the eyelid, predominantly in peri-Meibomian gland distribution. Review of the literature identified 10 previously reported cases of tarsal nevi with detailed clinicopathologic correlation in 3 of these patients. Conclusions Tarsal conjunctival nevi are rare. Adult presentation; subjective and objective evidence of growth; and associated inflammation, vascularity, and eyelid margin changes may make clinical distinction of tarsal nevi from melanoma challenging. Biopsy, therefore, is prudent as histopathology alone allows documentation of the benign nature of these lesions.
- Subjects :
- Adult
Male
Conjunctival Neoplasm
medicine.medical_specialty
Pathology
Conjunctival Neoplasms
Eyelid Neoplasms
Biopsy
Biomarkers, Tumor
medicine
Humans
Nevus
skin and connective tissue diseases
neoplasms
Aged
Nevus, Pigmented
integumentary system
medicine.diagnostic_test
business.industry
Melanoma
Madarosis
General Medicine
Middle Aged
Eyelid Neoplasm
medicine.disease
Immunohistochemistry
Dermatology
body regions
Ophthalmology
medicine.anatomical_structure
Child, Preschool
Female
Surgery
Histopathology
sense organs
Eyelid
business
Subjects
Details
- ISSN :
- 07409303
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Ophthalmic Plastic & Reconstructive Surgery
- Accession number :
- edsair.doi.dedup.....e5ed7a06cd61bbb5ce64affeb04068d0