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Ongoing Lithium Treatment Prevents Relapse After Total Sleep Deprivation
- Source :
- Journal of Clinical Psychopharmacology. 19:240-245
- Publication Year :
- 1999
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1999.
-
Abstract
- Forty bipolar depressed inpatients underwent three consecutive cycles of total sleep deprivation (TSD). At the beginning of the study, 20 patients were free of psychotropic drugs and 20 had been receiving Lithium medication for at least 6 months. Mood was rated on the Hamilton Rating Scale for Depression before and after TSD; perceived mood changes during treatment were evaluated with self-administered visual analog scales. Patients undergoing long-term lithium treatment showed a significantly better response to TSD as rated on both scales: 13 of 30 patients (rs. 2 of 20 patients without Lithium) showed a sustained response during a follow-up period of 3 months. This preliminary evidence of a positive interaction of TSD and long-term Lithium treatment could be explained by a synergistic effect of both treatments on brain serotonergic function, possibly via a desensitization of 5-hydroxytryptamine-1A inhibitory autoreceptors.
- Subjects :
- Male
endocrine system
Bipolar Disorder
Lithium (medication)
Visual analogue scale
Lithium
Serotonergic
chemistry.chemical_compound
Secondary Prevention
medicine
Humans
Pharmacology (medical)
Bipolar disorder
Lithium carbonate
Hamilton Rating Scale for Depression
Middle Aged
medicine.disease
Privation
Psychiatry and Mental health
Mood
chemistry
Anesthesia
Sleep Deprivation
Female
Psychology
medicine.drug
Subjects
Details
- ISSN :
- 02710749
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Psychopharmacology
- Accession number :
- edsair.doi.dedup.....e5e65b21539955763c5d4901a91ca33d