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Hepatitis B virus X upregulates HuR protein level to stabilize HER2 expression in hepatocellular carcinoma cells
- Source :
- BioMed Research International, BioMed Research International, Vol 2014 (2014)
- Publication Year :
- 2013
-
Abstract
- Hepatitis B virus- (HBV-) associated hepatocellular carcinoma (HCC) is the most common type of liver cancer. However, the underlying mechanism of HCC tumorigenesis is very complicated and HBV-encoded X protein (HBx) has been reported to play the most important role in this process. Activation of downstream signal pathways of epidermal growth factor receptor (EGFR) family is known to mediate HBx-dependent HCC tumor progression. Interestingly, HER2 (also known as ErbB2/Neu/EGFR2) is frequently overexpressed in HBx-expressing HCC patients and is associated with their poor prognosis. However, it remains unclear whether and how HBx regulates HER2 expression. In this study, our data showed that HBx expression increased HER2 protein level via enhancing its mRNA stability. The induction of RNA-binding protein HuR expression by HBx mediated the HER2 mRNA stabilization. Finally, the upregulated HER2 expression promoted the migration ability of HBx-expressing HCC cells. These findings deciphered the molecular mechanism of HBx-mediated HER2 upregulation in HBV-associated HCC.
- Subjects :
- Hepatitis B virus
Article Subject
Receptor, ErbB-2
viruses
RNA Stability
lcsh:Medicine
medicine.disease_cause
General Biochemistry, Genetics and Molecular Biology
medicine
Humans
Viral Regulatory and Accessory Proteins
Epidermal growth factor receptor
RNA, Messenger
RNA, Neoplasm
skin and connective tissue diseases
neoplasms
General Immunology and Microbiology
biology
lcsh:R
Liver Neoplasms
General Medicine
MRNA stabilization
Hep G2 Cells
medicine.disease
digestive system diseases
Up-Regulation
Gene Expression Regulation, Neoplastic
HBx
ELAV Proteins
Tumor progression
Hepatocellular carcinoma
Immunology
Cancer research
biology.protein
Trans-Activators
Carcinogenesis
Liver cancer
Research Article
Subjects
Details
- ISSN :
- 23146141
- Volume :
- 2014
- Database :
- OpenAIRE
- Journal :
- BioMed research international
- Accession number :
- edsair.doi.dedup.....e5dc29b96737db3dd996a005647fb6b6