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MRI and PET/CT for evaluation of the pathological response to neoadjuvant chemotherapy in breast cancer: A systematic review and meta-analysis
- Source :
- The Breast. 40:106-115
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Background Neoadjuvant chemotherapy (NAC) has become an essential treatment for breast cancer. However, there is still no consensus on the best tool to evaluate pathological response to NAC. Methods Two reviewers systematically searched Cochrane, PubMed, EMBASE, Web of Science, and CBM (last updated in February 2017) for eligible articles. We independently screened and selected studies that conformed to the inclusion criteria and extracted the requisite data. Pooled sensitivity, specificity, and the area under the SROC curve were calculated to estimate the diagnostic accuracy of magnetic resonance imaging (MRI) and positron emission computed tomography (PET/CT). And the relative DOR (RDOR) was used to compare accuracy for levels of the covariable. Results Thirteen studies involving 575 patients who underwent MRI and 618 who underwent PET/CT were included in our analysis. The pooled sensitivity and specificity of MRI were 0.88 (95% CI: 0.78–0.94) and 0.69 (95% CI: 0.51–0.83), respectively. The corresponding values for PET/CT were 0.77 (95% CI: 0.58–0.90) and 0.78 (95% CI: 0.63–0.88), respectively. The area under the SROC curve for MRI and PET/CT were 0.88 and 0.84, respectively. And the RDOR = 1.44 (95% CI, 0.46–4.47 P = 0.83). Conclusion MRI had a higher sensitivity and PET/CT had a higher specificity in predicting the pathologic response after NAC in patients with breast cancer. According to the area under the SROC curve and anatomic discriminative resolution, MRI is the more suitable recommendation for predicting the pathologic response after NAC.
- Subjects :
- Adult
medicine.medical_treatment
Breast Neoplasms
Pathological response
Sensitivity and Specificity
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Breast cancer
Positron Emission Tomography Computed Tomography
Outcome Assessment, Health Care
Humans
Medicine
In patient
Breast
Positron emission
Aged
PET-CT
Chemotherapy
medicine.diagnostic_test
business.industry
Magnetic resonance imaging
General Medicine
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Neoadjuvant Therapy
Treatment Outcome
ROC Curve
Chemotherapy, Adjuvant
Area Under Curve
030220 oncology & carcinogenesis
Meta-analysis
Female
Surgery
business
Nuclear medicine
Subjects
Details
- ISSN :
- 09609776
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- The Breast
- Accession number :
- edsair.doi.dedup.....e5d6f6690832e85ed3a317bee06e5792