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Impact of Elevated Donor Troponin I as Predictor of Adverse Outcome in Adult Heart Transplantation: A Single-center Experience
- Source :
- The Thoracic and Cardiovascular Surgeon. 66:417-424
- Publication Year :
- 2017
- Publisher :
- Georg Thieme Verlag KG, 2017.
-
Abstract
- Background Due to globally increasing donor organ shortage, investigation of previously described risk factors for utilizing marginal donor hearts is needed. The aim of this study was to determine the impact of elevated donor serum troponin I (TnI) levels on outcome after heart transplantation (HTx). Methods Between January 1996 and August 2013, 161 patients were reviewed for donor TnI serum levels (>0.3 ng/mL was considered elevated), postoperative outcome parameters, 30-day mortality, and 1-, 3-, and 5-year survival. Results TnI levels were elevated in 45 (28.0%) donors. Recipients of hearts with elevated TnI had higher incidence of postoperative systolic dysfunction, prolonged inotropic support, prolonged mechanical ventilation, and longer intensive care unit (ICU) stay (p Conclusions Elevated donor TnI serum concentration seems to be a marker for adverse outcome and increased short- and long-term mortality after HTx. Nevertheless, many other perioperative variables and parameters can be associated with outcome.
- Subjects :
- Adult
Male
Pulmonary and Respiratory Medicine
Inotrope
medicine.medical_specialty
Time Factors
medicine.medical_treatment
Kaplan-Meier Estimate
030204 cardiovascular system & hematology
030230 surgery
Single Center
Donor Selection
law.invention
03 medical and health sciences
Postoperative Complications
0302 clinical medicine
Risk Factors
law
Germany
Internal medicine
Troponin I
medicine
Humans
Retrospective Studies
Mechanical ventilation
Heart transplantation
business.industry
Incidence (epidemiology)
Perioperative
Middle Aged
Intensive care unit
Tissue Donors
Up-Regulation
Surgery
Treatment Outcome
Cardiology
Heart Transplantation
Female
Cardiology and Cardiovascular Medicine
business
Biomarkers
Subjects
Details
- ISSN :
- 14391902 and 01716425
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- The Thoracic and Cardiovascular Surgeon
- Accession number :
- edsair.doi.dedup.....e5cb58036d4fdf7e1ddff8d7e999103f