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Cell Culture-Based Assessment of Toxicity and Therapeutics of Phytochemical Antioxidants

Authors :
Peace C. Asuzu
Nicholas S. Trompeter
Carlton R. Cooper
Samuel A. Besong
Alberta N. A. Aryee
Source :
Molecules, Vol 27, Iss 1087, p 1087 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Plant-derived natural products are significant resources for drug discovery and development including appreciable potentials in preventing and managing oxidative stress, making them promising candidates in cancer and other disease therapeutics. Their effects have been linked to phytochemicals such as phenolic compounds and their antioxidant activities. The abundance and complexity of these bio-constituents highlight the need for well-defined in vitro characterization and quantification of the plant extracts/preparations that can translate to in vivo effects and hopefully to clinical use. This review article seeks to provide relevant information about the applicability of cell-based assays in assessing anti-cytotoxicity of phytochemicals considering several traditional and current methods.

Details

ISSN :
14203049
Volume :
27
Database :
OpenAIRE
Journal :
Molecules
Accession number :
edsair.doi.dedup.....e5c1d14c3a6980e3942d367cb6587de2