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Cell Culture-Based Assessment of Toxicity and Therapeutics of Phytochemical Antioxidants
- Source :
- Molecules, Vol 27, Iss 1087, p 1087 (2022)
- Publication Year :
- 2022
- Publisher :
- MDPI AG, 2022.
-
Abstract
- Plant-derived natural products are significant resources for drug discovery and development including appreciable potentials in preventing and managing oxidative stress, making them promising candidates in cancer and other disease therapeutics. Their effects have been linked to phytochemicals such as phenolic compounds and their antioxidant activities. The abundance and complexity of these bio-constituents highlight the need for well-defined in vitro characterization and quantification of the plant extracts/preparations that can translate to in vivo effects and hopefully to clinical use. This review article seeks to provide relevant information about the applicability of cell-based assays in assessing anti-cytotoxicity of phytochemicals considering several traditional and current methods.
- Subjects :
- Plant Extracts
Phytochemicals
Organic Chemistry
apoptosis
antioxidant activity
Pharmaceutical Science
cell lines
Antioxidants
Analytical Chemistry
Oxidative Stress
QD241-441
Chemistry (miscellaneous)
Toxicity Tests
Drug Discovery
Animals
Humans
cytotoxicity
Molecular Medicine
Physical and Theoretical Chemistry
bioprinting
medicinal plants
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....e5c1d14c3a6980e3942d367cb6587de2