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Cytomegalovirus Pneumonia with Progressive Lung Volume Loss
- Source :
- The American Journal of Case Reports
- Publication Year :
- 2018
- Publisher :
- International Scientific Information, Inc., 2018.
-
Abstract
- Case series Patients: Male, 65 • Male, 63 • Female, 35 Final Diagnosis: CMV pneumonia Symptoms: Respiratory failure Medication: — Clinical Procedure: Excepting diagnosis Specialty: Pulmonology Objective: Unusual clinical course Background: Cytomegalovirus (CMV) pneumonia is common in immunocompromised patients with hematological malignancies. Although the spectrum of illness caused by CMV is well-documented in immunocompromised patients, the clinical course and evolution of lung changes after initiation of antiviral therapy remain unclear. Case Report: We present the cases of 3 patients with leukemia who developed CMV pneumonia following cord blood transplantation and who presented with distinctive features on chest computed tomography (CT). In all patients, chest CT showed central peribronchial changes with severe lung volume loss. Furthermore, the patients were refractory to high-dose steroids, and the lung volume loss rapidly progressed, leading to death from respiratory failure. Conclusions: We observed central peribronchial changes with severe lung volume loss after the acute phase in 3 cases of CMV pneumonia. While our diagnosis was made on the basis of exclusion, it is important to bear in mind that lung involvement in CMV pneumonia may be refractory to various treatment modalities and can lead to a fatal clinical course.
- Subjects :
- Adult
Male
medicine.medical_specialty
Congenital cytomegalovirus infection
Cytomegalovirus
Gastroenterology
03 medical and health sciences
Fatal Outcome
0302 clinical medicine
Refractory
Internal medicine
medicine
Humans
Lung volumes
Aged
Leukemia
Lung
business.industry
Pneumonia
Articles
General Medicine
Middle Aged
medicine.disease
respiratory tract diseases
medicine.anatomical_structure
030228 respiratory system
Respiratory failure
Cryptogenic Organizing Pneumonia
030220 oncology & carcinogenesis
Cytomegalovirus Infections
Female
Cord Blood Stem Cell Transplantation
Respiratory Insufficiency
Tomography, X-Ray Computed
business
Subjects
Details
- ISSN :
- 19415923
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- American Journal of Case Reports
- Accession number :
- edsair.doi.dedup.....e5b56308d24bd06a62861e77b3162d4f