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Orexins (hypocretins): The intersection between homeostatic and hedonic feeding
- Source :
- Journal of neurochemistryREFERENCES. 157(5)
- Publication Year :
- 2021
-
Abstract
- Orexins are hypothalamic neuropeptides originally discovered to play a role in the regulation of feeding behaviour. The broad connections of orexin neurons to mesocorticolimbic circuitry suggest they may play a role in mediating reward-related behaviour beyond homeostatic feeding. Here, we review the role of orexin in a variety of eating-related behaviour, with a focus on reward and motivation, and the neural circuits driving these effects. One emerging finding is the involvement of orexins in hedonic and appetitive behaviour towards palatable food, in addition to their role in homeostatic feeding. This review discusses the brain circuitry and possible mechanisms underlying the role of orexins in these behaviours. Overall, there is a marked bias in the literature towards studies involving male subjects. As such, future work needs to be done to involve female subjects. In summary, orexins play an important role in driving motivation for high salient rewards such as highly palatable food and may serve as the intersection between homeostatic and hedonic feeding.
- Subjects :
- 0301 basic medicine
Hypothalamic neuropeptides
Biochemistry
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Reward
Orexin Receptors
mental disorders
Biological neural network
Food seeking
Animals
Homeostasis
Humans
Orexins
digestive, oral, and skin physiology
Feeding Behavior
Orexin
Philosophy
030104 developmental biology
nervous system
Food
Psychology
Neuroscience
psychological phenomena and processes
030217 neurology & neurosurgery
Brain circuitry
Subjects
Details
- ISSN :
- 14714159
- Volume :
- 157
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of neurochemistryREFERENCES
- Accession number :
- edsair.doi.dedup.....e5b246aafd353cdf4860cf4f6f9045cd