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Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
- Source :
- Clasen, J L, Heath, A K, Van Puyvelde, H, Huybrechts, I, Park, J Y, Ferrari, P, Scelo, G, Ulvik, A, Midttun, Ø, Ueland, P M, Overvad, K, Eriksen, A K, Tjønneland, A, Kaaks, R, Katzke, V, Schulze, M B, Palli, D, Agnoli, C, Chiodini, P, Tumino, R, Sacerdote, C, Zamora-Ros, R, Rodriguez-Barranco, M, Santiuste, C, Ardanaz, E, Amiano, P, Schmidt, J A, Weiderpass, E, Gunter, M, Riboli, E, Cross, A J, Johansson, M & Muller, D C 2022, ' Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study ', International Journal of Cancer, vol. 151, no. 5, pp. 708-716 . https://doi.org/10.1002/ijc.34009
- Publication Year :
- 2022
-
Abstract
- Previous studies have suggested that components of one-carbon metabolism, particularly circulating vitamin B6, have an etiological role in renal cell carcinoma (RCC). Vitamin B6 is a cofactor in the transsulfuration pathway. We sought to holistically investigate the role of the transsulfuration pathway in RCC risk. We conducted a nested case-control study (455 RCC cases and 455 matched controls) within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Plasma samples from the baseline visit were analyzed for metabolites of the transsulfuration pathway, including pyridoxal 5'-phosphate (PLP, the biologically active form of vitamin B6), homocysteine, serine, cystathionine, and cysteine, in addition to folate. Bayesian conditional logistic regression was used to estimate associations of metabolites with RCC risk as well as interactions with established RCC risk factors. Circulating PLP and cysteine were inversely associated with RCC risk, and these associations were not attenuated after adjustment for other transsulfuration metabolites (odds ratio (OR) and 90% credible interval (CrI) per 1 SD increase in log concentration: 0.76 [0.66, 0.87]; 0.81 [0.66, 0.96], respectively). A comparison of joint metabolite profiles suggested substantially greater RCC risk for the profile representative of low overall transsulfuration function compared to high function (OR 2.70 [90% CrI 1.26, 5.70]). We found some statistical evidence of interactions of cysteine with body mass index, and PLP and homocysteine with smoking status, on their associations with RCC risk. In conclusion, we found evidence suggesting that the transsulfuration pathway may play a role in metabolic dysregulation leading to RCC development. ispartof: INTERNATIONAL JOURNAL OF CANCER vol:151 issue:5 pages:708-716 ispartof: location:United States status: published
- Subjects :
- Cancer Research
dietary biomarkers
transsulfuration
dietary biomarker
HOMOCYSTEINE
METABOLISM
urologic and male genital diseases
vitamin B6
SERUM
INFLAMMATION
Humans
1112 Oncology and Carcinogenesis
ASSAY
AMINO-ACIDS
Oncology & Carcinogenesis
Cysteine
Prospective Studies
Carcinoma, Renal Cell
Homocysteine
Carcinoma, Renal Cell/epidemiology
Science & Technology
Kidney Neoplasms/epidemiology
PLASMA
kidney cancer
Bayes Theorem
Kidney Neoplasms
Vitamin B 6
Oncology
VITAMIN-B-12
Case-Control Studies
Pyridoxal Phosphate
CYSTEINE
Life Sciences & Biomedicine
Biomarkers
FOLATE
Subjects
Details
- ISSN :
- 10970215
- Volume :
- 151
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- International journal of cancer
- Accession number :
- edsair.doi.dedup.....e5b057b41415a5867064b2c0b51e3d4b