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Radiation therapy for intracranial tumours in cats with neurological signs
- Source :
- Journal of Feline Medicine and Surgery. 21:765-771
- Publication Year :
- 2018
- Publisher :
- SAGE Publications, 2018.
-
Abstract
- Objectives The aim of this study was to evaluate the outcome of cats with intracranial tumours presenting with neurological signs treated with radiation therapy. Methods This study comprised a retrospective multicentre case series. Medical records of a total of 22 cats with intracranial space-occupying lesions, presenting with neurological signs and/or epileptic seizures and treated with external beam radiation therapy, were reviewed. In the treated cats, patient-, tumour- and treatment-related variables were investigated, including age, sex, tumour location, tumour volume, total radiation dose, equivalent dose in 2 Gy fractions (EQD2), corticosteroid dose, overall treatment time and institution for influence on local tumour control and survival. Results Based on advanced imaging characteristics, the 22 treated cats presented with meningioma (n = 11), pituitary tumour (n = 8), choroid plexus tumour (n = 2) or glioma (n = 1). Allocated to the neuraxis, 11 lesions were extra-axial, three were intra-axial and eight were located in the pituitary region. At diagnosis, 21 cats exhibited altered neurological status. One cat presented with epileptic seizures and another cat had both seizures and altered neurological status. The mean total physical dose of radiation was 41.63 Gy (± 4.33), range 24–45 Gy. In all but one cat (95.5%), neurological signs improved after radiation therapy. The median progression-free survival was 510 days (95% confidence interval [CI]: 51–969). The proportion free of progression at 1 year was 55.7% (95% CI: 33–78). Fourteen cats died (only in five cases was death related to the intracranial tumour) and eight cats were still alive or lost to follow-up. The median overall survival time was 515 days (95% CI: 66–964). None of the tested variables influenced outcome. Conclusions and relevance Radiation therapy seems to represent a viable treatment option in cats with intracranial tumours, relieving neurological signs and improving local tumour control. Radiation therapy may be considered for cats with tumours in complicated/inoperable localisations or for cases with a high peri- and postoperative risk.
- Subjects :
- Neurological signs
intracranial
medicine.medical_specialty
10253 Department of Small Animals
040301 veterinary sciences
medicine.medical_treatment
Cat Diseases
meningioma
pituitary
radiation therapy
030308 mycology & parasitology
0403 veterinary science
Meningioma
03 medical and health sciences
glioma
Glioma
medicine
Animals
Intracranial tumours
Small Animals
radiotherapy
Retrospective Studies
0303 health sciences
CATS
630 Agriculture
Brain Neoplasms
business.industry
Brain tumour
10060 Epidemiology, Biostatistics and Prevention Institute (EBPI)
04 agricultural and veterinary sciences
medicine.disease
Radiation therapy
Cats
3404 Small Animals
570 Life sciences
biology
Radiology
business
Subjects
Details
- ISSN :
- 15322750 and 1098612X
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Journal of Feline Medicine and Surgery
- Accession number :
- edsair.doi.dedup.....e5add097cec9b08b3841e79b2abb9763