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Significance of broad distribution of electron-dense deposits in patients with IgA nephropathy
- Source :
- Medical molecular morphology. 45(1)
- Publication Year :
- 2010
-
Abstract
- Immunoglobulin A nephropathy (IgAN) is characterized by mesangial cell proliferation and mesangial expansion with mesangial depositions of IgA. We have found that electron-dense deposits (EDD) are often observed in areas other than paramesangial areas in glomeruli. To compare electron microscopic findings with light microscopic findings and clinical data, we examined the biopsies from 178 patients with IgAN. Patients were divided into two groups: group A had only paramesangial deposits and group B had deposits not only in paramesangial areas but also in other areas. All patients examined in this study had EDD in glomerular paramesangial areas. Thirty-six patients were included in group B. Cellular crescent formation in glomeruli and urinary protein in group B were significantly higher than those in group A (P < 0.01). Serum albumin and estimated glomerular filtration rate (eGFR) in group B were significantly lower than those in group A (P < 0.05). Group B showed a significant positive correlation with histological severity, which is defined in the Japanese Clinical Guidelines on IgAN. In patients with broad distribution of EDD, urinary protein was significantly increased (P < 0.05). Detailed observation of EDD distribution has an impact on evaluation of the disease activity of IgAN.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Biopsy
Kidney Glomerulus
Serum albumin
Renal function
urologic and male genital diseases
Group A
Group B
Pathology and Forensic Medicine
Nephropathy
Young Adult
medicine
Distribution (pharmacology)
Humans
In patient
Molecular Biology
biology
Chemistry
Glomerulonephritis, IGA
General Medicine
medicine.disease
Molecular medicine
Glomerular Mesangium
Microscopy, Electron
biology.protein
Female
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 18601499
- Volume :
- 45
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Medical molecular morphology
- Accession number :
- edsair.doi.dedup.....e59fce19ea121cec138c07d746950128