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Prevalence of post-COVID-19 symptoms in hospitalized and non-hospitalized COVID-19 survivors: A systematic review and meta-analysis
- Source :
- European Journal of Internal Medicine
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Background Single studies support the presence of several post-COVID-19 symptoms; however, no meta-analysis differentiating hospitalized and non-hospitalized patients has been published to date. This meta-analysis analyses the prevalence of post-COVID-19 symptoms in hospitalized and non-hospitalized patients recovered from COVID-19 . Methods MEDLINE, CINAHL, PubMed, EMBASE, and Web of Science databases, as well as medRxiv and bioRxiv preprint servers were searched up to March 15, 2021. Peer-reviewed studies or preprints reporting data on post-COVID-19 symptoms collected by personal, telephonic or electronic interview were included. Methodological quality of the studies was assessed using the Newcastle-Ottawa Scale. We used a random-effects models for meta-analytical pooled prevalence of each post-COVID-19 symptom, and I² statistics for heterogeneity. Data synthesis was categorized at 30, 60, and ≥90 days after . Results From 15,577 studies identified, 29 peer-reviewed studies and 4 preprints met inclusion criteria. The sample included 15,244 hospitalized and 9011 non-hospitalized patients. The methodological quality of most studies was fair. The results showed that 63.2, 71.9 and 45.9% of the sample exhibited ≥one post-COVID-19 symptom at 30, 60, or ≥90days after onset/hospitalization. Fatigue and dyspnea were the most prevalent symptoms with a pooled prevalence ranging from 35 to 60% depending on the follow-up. Other post-COVID-19 symptoms included cough (20–25%), anosmia (10–20%), ageusia (15–20%) or joint pain (15–20%). Time trend analysis revealed a decreased prevalence 30days after with an increase after 60days . Conclusion This meta-analysis shows that post-COVID-19 symptoms are present in more than 60% of patients infected by SARS-CoV‑2. Fatigue and dyspnea were the most prevalent post-COVID-19 symptoms, particularly 60 and ≥90 days after.
- Subjects :
- medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Anosmia
MEDLINE
CINAHL
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Internal medicine
Prevalence
Internal Medicine
medicine
030212 general & internal medicine
Fatigue
business.industry
Data synthesis
Ageusia
Meta-analysis
Dyspnea
Joint pain
Symptoms
Original Article
medicine.symptom
Covid-19
business
Subjects
Details
- ISSN :
- 09536205
- Volume :
- 92
- Database :
- OpenAIRE
- Journal :
- European Journal of Internal Medicine
- Accession number :
- edsair.doi.dedup.....e593adbaec1c11a3af66715745f802c8
- Full Text :
- https://doi.org/10.1016/j.ejim.2021.06.009