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Primary Bone Marrow Progenitors of Both Granulocytic and Monocytic Lineages Are Susceptible to Infection with the Agent of Human Granulocytic Ehrlichiosis
- Source :
- The Journal of Infectious Diseases. 176:1405-1409
- Publication Year :
- 1997
- Publisher :
- Oxford University Press (OUP), 1997.
-
Abstract
- Human granulocytic ehrlichiosis (HGE) is an emerging tickborne infection resulting in an acute febrile illness associated with cytopenias and characteristic intracellular organisms within peripheral blood granulocytes. The etiologic agent of HGE has recently been isolated and cultivated in the HL-60 promyelocytic leukemia cell line, but the spectrum of host cells that it naturally infects remains unknown. To determine if normal hematopoietic progenitors could be targets of infection, CD34 + primary human bone marrow cells, stimulated to differentiate along myelomonocytic lineages, were incubated with the HGE agent. Immature marrow progenitors and, remarkably, not only granulocytic but also CD14 + monocytic cells from these cultures supported replication of the HGE agent, suggesting that all are potential targets of infection in vivo. Infection of bone marrow progenitors may contribute to the hematologic manifestations of HGE. Furthermore, the ability of the agent to interact with monocytes has significant implications regarding disease pathogenesis and host response.
- Subjects :
- Acute promyelocytic leukemia
medicine.medical_specialty
Ehrlichiosis
Hematology
Ehrlichia
CD34
HL-60 Cells
Granulocyte
Biology
Hematopoietic Stem Cells
medicine.disease
Virology
Monocytes
Haematopoiesis
Infectious Diseases
medicine.anatomical_structure
Internal medicine
Immunology
medicine
Humans
Immunology and Allergy
Bone marrow
Stem cell
Cells, Cultured
Granulocytes
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 176
- Database :
- OpenAIRE
- Journal :
- The Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....e582d64e8b11a5e65334eb69d9d6a49f