Changes in Weight and Metabolic Syndrome Are Associated With Prostate Growth Rate Over a 5-Year Period

Objective To evaluate the relationship between changes in weight, waist circumference (WC), metabolic syndrome (MetS), and prostate growth over 5 years in the adult population. Materials and Methods Data were collected from 1088 adult men (age ≥40 years) without history of prostate cancer who underwent more than 2 general health screenings between 2006 and 2013. Percent changes in prostate volume (PV) were assessed for 5 years after baseline measurements. Associations between prostate growth and change in weight, WC and MetS status, respectively, were calculated using uni- and multivariate linear regression analyses. Results During the 5 years, the median PV changes were 1.3 cc/year corresponding to a median growth rate of 6.2%/year. By multivariate linear regression analysis, change in weight was significantly associated with prostate growth ( P 2 ) (0.150; 95% confidence interval [CI], 0.425-1.547; P .01) but not in nonobese men (initial BMI 2 ) (0.054; 95% CI, −0.176 to 0. 858; P = .20). Patients with newly developed MetS showed greater prostate growth than those who did not have MetS (6.796; 95% CI, 1.599-12.003; P = .01). Conclusion Changes in weight, WC and newly diagnosed MetS affected prostate growth rate during 5 years. Reducing weight and controlling MetS could decrease the prostate growth rate.