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Immunotherapy and stereotactic ablative radiotherapy (ISABR): a curative approach?
- Publication Year :
- 2016
-
Abstract
- Conventional radiotherapy, in addition to its well-established tumoricidal effects, can also activate the host immune system. Radiation therapy modulates tumour phenotypes, enhances antigen presentation and tumour immunogenicity, increases production of cytokines and alters the tumour microenvironment, enabling destruction of the tumour by the immune system. Investigating the combination of radiotherapy with immunotherapeutic agents, which also promote the host antitumour immune response is, therefore, a logical progression. As the spectrum of clinical use of stereotactic radiotherapy continues to broaden, the question arose as to whether the ablative radiation doses used can also stimulate immune responses and, if so, whether we can amplify these effects by combining immunotherapy and stereotactic ablative radiotherapy (SABR). In this Perspectives article, we explore the preclinical and clinical evidence supporting activation of the immune system following SABR. We then examine studies that provide data on the effectiveness of combining these two techniques - immunotherapy and SABR - in an approach that we have termed 'ISABR'. Lastly, we provide general guiding principles for the development of future clinical trials to investigate the efficacy of ISABR in the hope of generating further interest in these exciting developments.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
medicine.medical_treatment
Programmed Cell Death 1 Receptor
SABR volatility model
Antibodies, Monoclonal, Humanized
Radiosurgery
Article
03 medical and health sciences
0302 clinical medicine
Immune system
Cancer immunotherapy
Internal medicine
Neoplasms
medicine
Combined Modality Therapy
Humans
CTLA-4 Antigen
Clinical Trials as Topic
business.industry
Immunotherapy
Radiation therapy
Clinical trial
030104 developmental biology
030220 oncology & carcinogenesis
Immunology
business
Forecasting
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....e55595b277e06454c92593e54de6ffb7