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Souvenaid Reduces Behavioral Deficits and Improves Social Cognition Skills in Frontotemporal Dementia: A Proof-of-Concept Study
- Source :
- Neurodegenerative Diseases. 15:58-62
- Publication Year :
- 2015
- Publisher :
- S. Karger AG, 2015.
-
Abstract
- Background: Souvenaid™ is a nutraceutical compound thought to positively enhance synaptic function. In line with this mechanism of action, Souvenaid™ has been shown to improve cognitive function in subjects with mild Alzheimer's disease in randomized clinical trials. To date, however, the potential of Souvenaid™ to improve cognitive functioning in subjects with other neurodegenerative conditions also characterized by synaptic loss has not been explored. Objective: To evaluate the impact of Souvenaid™ on executive functions, social cognition and behavioral disturbances in subjects with the behavioral variant of frontotemporal dementia (bv-FTD). Methods: Twenty-six subjects with bv-FTD were enrolled in the study and randomized to Souvenaid™ (125 ml/day) or placebo groups. After 12 weeks, subjects were switched between the two groups. All subjects, blinded to treatment, underwent clinical and cognitive evaluations at enrollment, after 12 weeks and after 24 weeks. Results: Treatment with Souvenaid™ was associated with a significant reduction of behavioral symptoms and an increase in Theory of Mind skills compared to placebo, which both returned to baseline when Souvenaid™ was discontinued. Souvenaid™ did not have an effect on executive functions. Conclusions: Our results provide evidence of the potential of Souvenaid™ therapy for the treatment of behavioral disturbances and social cognition skills in FTD.
- Subjects :
- Male
Outcome Assessment
Docosahexaenoic Acids
health care facilities, manpower, and services
education
Treatment outcome
Behavioral deficits
Neuropsychological Tests
Outcome assessment
Fronto-temporal dementia
Choline
Social Skills
Executive Function
Selenium
Cognition
Folic Acid
Social skills
Social cognition
Outcome Assessment, Health Care
mental disorders
medicine
Humans
Aged
Mental Disorders
Medical foods
Eicosapentaenoic Acid
Female
Frontotemporal Dementia
Middle Aged
Synapses
Treatment Outcome
Uridine Monophosphate
Dietary Supplements
Souvenaid
medicine.disease
Health Care
Settore MED/01
Synaptic function
Neurology
Proof of concept
Neurology (clinical)
Psychology
Neuroscience
Frontotemporal dementia
medicine.drug
Cognitive psychology
Subjects
Details
- ISSN :
- 16602862 and 16602854
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Neurodegenerative Diseases
- Accession number :
- edsair.doi.dedup.....e553f0a3d15ab9967a8955018d1056a1