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Implementation and quantitative evaluation of analytical methods for attenuation correction in SPECT: a phantom study
- Source :
- Physics in Medicine and Biology. 44:2643-2655
- Publication Year :
- 1999
- Publisher :
- IOP Publishing, 1999.
-
Abstract
- Three differing exact methods of inverting the two-dimensional (2D) exponential Radon transform were implemented and evaluated quantitatively with a phantom study. The phantom had the shape of a pie-chart divided into six cavities, each 480 ml in volume and 10 cm in height, that were symmetrically positioned in a cylinder that was 20 cm in diameter and 10 cm in height. This phantom tests for linearity between true activity concentration and measured activity concentration, and it is denoted as a linearity phantom in the present study. Each cavity contained a different concentration of a homogeneous solution of 99mTc (74, 148, 222, 296, 370 and 444 kBq ml(-1)). Data acquisition was performed with two energy windows: a 20% photopeak energy window set symmetrically over the 140 keV of 99mTc and a secondary 5% energy window set over the 122 keV peak. We optimized a triple-energy window scatter correction method for a gamma camera-collimator system to obtain accurate scatter-corrected projections. A circular ROI 3 cm in diameter was identified over each cavity region, and count density (counts per pixel) was calculated. This value was converted to activity concentration (kBq ml(-1)) using a cross-calibration coefficient between SPECT counts and the gamma well counter. The relation between true activity (x) and measured activity concentration (y) was fitted to a line using the least-squares method. Regression lines were y = 0.63 + 1.0255x (R2 = 0.9987), y = -2.62 + 1.0278x (R2 = 0.9995), and y = 0.092 + 1.0241x (R2 = 0.9989) for the Bellini, Inouye and Metz-Pan methods respectively. In another phantom study using two different types of phantoms, contrast of a cold region in the two was 96% and 101% for all three methods. Combined optimized scatter correction and analytical attenuation correction methods achieve good accuracy in quantification of activity distribution with a uniform attenuating medium.
- Subjects :
- Tomography, Emission-Computed, Single-Photon
Physics
Radiological and Ultrasound Technology
Radon transform
Phantoms, Imaging
business.industry
Reproducibility of Results
Technetium
Linearity
For Attenuation Correction
Well counter
Imaging phantom
law.invention
Optics
law
Attenuation coefficient
Linear regression
Image Processing, Computer-Assisted
Humans
Regression Analysis
Radiology, Nuclear Medicine and imaging
business
Correction for attenuation
Subjects
Details
- ISSN :
- 13616560 and 00319155
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Physics in Medicine and Biology
- Accession number :
- edsair.doi.dedup.....e5295c90f44229f1be28f9d51a247f1c