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The Waveform Fluctuation and the Clinical Factors of the Initial and Sustained Erythropoietic Response to Continuous Erythropoietin Receptor Activator in Hemodialysis Patients
- Source :
- The Scientific World Journal, Vol 2012 (2012), The Scientific World Journal
- Publication Year :
- 2012
- Publisher :
- Hindawi Limited, 2012.
-
Abstract
- Objectives. Erythropoiesis-stimulating agents (ESA) are the main treatment for anemia in hemodialysis (HD) patients. We evaluated factors determining the response after treatment of a new ESA (continuous erythropoietin erythropoietin receptor activator (CERA)).Methods. 61 HD patients were classified by their response at two different timings. First, patients whose hematocrit (Hct) increased 1.5% in the first week were defined as initial responders (IR,n=16). We compared several parameters between IR and the rest of the study subjects (non-IR,n=45). Second, patients whose Hct increased 2% in the 4th week were defined as sustained responders (SR,n=12), and we did a similar comparison.Results. The Hct showed a waveform fluctuation. Compared with the rest, IR had significantly lower platelet counts and higher levels of ferritin, total protein, total bilirubin, and serum sodium, while SR had significantly lower levels of C-reactive protein and low-density lipoprotein (AllP<0.05). In comparison with the rest, higher Hct persisted for 10 weeks in SR but only for two separate weeks (the 1st and 7th week) in IR.Conclusions. The initial and sustained erythropoietic responses are independent from each other and are associated with different factors. Treatment focusing on these factors may improve the response.
- Subjects :
- medicine.medical_specialty
Article Subject
Bilirubin
Anemia
medicine.medical_treatment
lcsh:Medicine
Hematocrit
lcsh:Technology
General Biochemistry, Genetics and Molecular Biology
chemistry.chemical_compound
Renal Dialysis
hemic and lymphatic diseases
Internal medicine
Receptors, Erythropoietin
Humans
Medicine
lcsh:Science
Aged
General Environmental Science
Aged, 80 and over
biology
medicine.diagnostic_test
lcsh:T
business.industry
lcsh:R
General Medicine
Middle Aged
medicine.disease
Continuous erythropoietin receptor activator
Erythropoietin receptor
Ferritin
Endocrinology
chemistry
Erythropoietin
Clinical Study
biology.protein
Female
lcsh:Q
Hemodialysis
business
medicine.drug
Subjects
Details
- ISSN :
- 1537744X
- Volume :
- 2012
- Database :
- OpenAIRE
- Journal :
- The Scientific World Journal
- Accession number :
- edsair.doi.dedup.....e51cac36f9cb5d780ce4ff1523375fff