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Pregabalin reduces alcohol drinking and relapse to alcohol seeking in the rat
- Publication Year :
- 2011
-
Abstract
- Pregabalin (Lyrica™) is a structural analogue of γ-aminobutyric acid (GABA) approved by FDA for partial epilepsy, neuropathic pain and recently generalized anxiety disorder. While the exact cellular mechanism of action of pregabalin is still unclear, evidence from several studies suggests that it reduces excitatory neurotransmitter release and postsynaptic excitability. Based on these mechanisms we sought interesting to evaluate the effect of pregabalin on alcohol-abuse-related behaviours. For this purpose, using genetically selected alcohol-preferring Marchigian Sardinian (msP) rats, we evaluated the effect of pregabalin on alcohol drinking and relapse to alcohol seeking elicited by environmental conditioning factors or stress. Our results showed that treatment with pregabalin (0, 10, 30 and 60 mg/kg) given orally selectively reduced home cage alcohol drinking in msP rat. This effect was confirmed in self-administration experiments where pregabalin (0, 10 and 30 mg/kg) significantly reduced operant responding for alcohol but not for food. Using alcohol reinstatement models we also found that pregabalin (0, 10 and 30 mg/kg) abolished seeking behaviour elicited by the pharmacological stressor yohimbine as well as cues predictive of alcohol availability. Results demonstrate that pregabalin may have potential in the treatment of alcohol addiction.
- Subjects :
- Male
Generalized anxiety disorder
Alcohol Drinking
media_common.quotation_subject
Drug-Seeking Behavior
Pregabalin
Alcohol
Self Administration
Pharmacology
chemistry.chemical_compound
Postsynaptic potential
Secondary Prevention
Medicine
Animals
Alcohol seeking
Selection, Genetic
gamma-Aminobutyric Acid
media_common
Dose-Response Relationship, Drug
Ethanol
business.industry
Addiction
Yohimbine
medicine.disease
Rats
chemistry
Neuropathic pain
Conditioning, Operant
Anticonvulsants
business
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....e50a7c13c9d15c9a2a6767a51808f421