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Diagnostic performance of 18 F‐FDG‐PET/CT in inflammation of unknown origin: A clinical series of 317 patients
- Source :
- Journal of Internal Medicine, Journal of Internal Medicine, In press, ⟨10.1111/joim.13452⟩
- Publication Year :
- 2022
- Publisher :
- Wiley, 2022.
-
Abstract
- International audience; Background: Inflammation of unknown origin (IUO) is a challenging situation in internal medicine.Objectives: To describe the final diagnoses in IUO and assess the helpfulness of 18F-fluorodesoxyglucose positron emission tomography with computerized tomography (18F-FDG-PET/CT) in the diagnosis strategy.Results: A total of 317 IUO patients with 18F-FDG-PET/CT were enrolled. A diagnosis was reached in 228 patients: noninfectious inflammatory diseases (NIID) (37.5%), infectious diseases (18.6%), malignancies (7.9%), and non-systemic-inflammatory miscellaneous diseases (7.9%). The two leading causes of NIID were polymyalgia rheumatica and giant cell arteritis. 18F-FDG-PET/CT results were classified as true positive in 49.8% of patients and contributory in 75.1% of overall IUO patients (after the complete investigation set and a prolonged follow-up). In multivariate analysis, only C-reactive protein minimum level (≥50 mg/L) was associated with the contributory status of 18F-FDG-PET/CT.Conclusion: Within the wide spectrum of IUO underlying diseases, 18F-FDG-PET/CT is helpful to make a diagnosis and to eliminate inflammatory diseases. Obese patients constitute a specific group needing further studies
Details
- ISSN :
- 13652796 and 09546820
- Volume :
- 291
- Database :
- OpenAIRE
- Journal :
- Journal of Internal Medicine
- Accession number :
- edsair.doi.dedup.....e5074e3986355439cdcf8c5cae570544