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COVID-19 Presenting as Major Thromboembolic Events: Virchow’s Triad Revisited and Clinical Considerations of Therapeutic Anticoagulation
- Source :
- Cureus
- Publication Year :
- 2020
- Publisher :
- Cureus, Inc., 2020.
-
Abstract
- This case series describes clinical course of three COVID-19 patients who presented with major thromboembolic events. Patient 1 is a 57-year-old male with asymptomatic COVID-19 who presented with a large left ventricular thrombus. His hospital course was complicated with a stroke. Patient 2 is a 71-year-old male with mild COVID-19 who presented with an acute stroke. Patient 3 is a 47-year-old male with severe COVID-19 who presented with a large pulmonary embolism. He died of a recurrent massive pulmonary embolism. This case series demonstrates that thromboembolic event can be the presenting feature of COVID-19 and can occur in the patients with asymptomatic or mild COVID-19. Diffuse endothelial injury and hypercoagulability play a pivotal role in recurrent thromboembolic events despite the anticoagulation. Therapeutic anticoagulation may be considered for severe COVID-19 patients and patients with important comorbidities or pre-existing endothelial dysfunction.
- Subjects :
- medicine.medical_specialty
thromboembolic event
Coronavirus disease 2019 (COVID-19)
Cardiology
hypercoagulable state
Infectious Disease
030204 cardiovascular system & hematology
Asymptomatic
03 medical and health sciences
0302 clinical medicine
Internal medicine
Medicine
Endothelial dysfunction
anticoagulation
Acute stroke
business.industry
General Engineering
Clinical course
Hematology
Left ventricular thrombus
medicine.disease
Pulmonary embolism
covid-19
virchow’s triad
medicine.symptom
business
Virchow's triad
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 21688184
- Database :
- OpenAIRE
- Journal :
- Cureus
- Accession number :
- edsair.doi.dedup.....e506970c929cd413b80cb7153326fc7d
- Full Text :
- https://doi.org/10.7759/cureus.10137