Back to Search Start Over

COVID-19 Presenting as Major Thromboembolic Events: Virchow’s Triad Revisited and Clinical Considerations of Therapeutic Anticoagulation

Authors :
Haoyi Zheng
Lin Wang
Kathleen Stergiopoulos
Jane Cao
Lu Chen
Source :
Cureus
Publication Year :
2020
Publisher :
Cureus, Inc., 2020.

Abstract

This case series describes clinical course of three COVID-19 patients who presented with major thromboembolic events. Patient 1 is a 57-year-old male with asymptomatic COVID-19 who presented with a large left ventricular thrombus. His hospital course was complicated with a stroke. Patient 2 is a 71-year-old male with mild COVID-19 who presented with an acute stroke. Patient 3 is a 47-year-old male with severe COVID-19 who presented with a large pulmonary embolism. He died of a recurrent massive pulmonary embolism. This case series demonstrates that thromboembolic event can be the presenting feature of COVID-19 and can occur in the patients with asymptomatic or mild COVID-19. Diffuse endothelial injury and hypercoagulability play a pivotal role in recurrent thromboembolic events despite the anticoagulation. Therapeutic anticoagulation may be considered for severe COVID-19 patients and patients with important comorbidities or pre-existing endothelial dysfunction.

Details

ISSN :
21688184
Database :
OpenAIRE
Journal :
Cureus
Accession number :
edsair.doi.dedup.....e506970c929cd413b80cb7153326fc7d
Full Text :
https://doi.org/10.7759/cureus.10137